Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model

The uric acid metabolism pathway is more similar in primates and humans than in rodents. However, there are no reports of using primates to establish animal models of hyperuricaemia (HUA).To establish an animal model highly related to HUA in humans.Inosine (75, 100 and 200 mg/kg) was intraperitoneally administered to adult male rhesus monkeys (n = 5/group). Blood samples were collected over 8 h, and serum uric acid (SUA) level was determined...