Does Reduced Renal Function Predispose to Cancer-specific Mortality from Renal Cell Carcinoma?

Recent publications have reported an association between increased renal cancer-specific mortality (CSM) and reduced renal function "below safety limits," and advocated for partial nephrectomy (PN) even for potentially aggressive/complex tumors. We hypothesize that this association may be related to confounding factors rather than a consequence of functional differences.To assess whether there is an independent association between preoperative...