Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing
Abstract
Excessive expression of matrix metalloproteinase 9 (MMP-9) impedes healing of diabetic chronic wounds, thus wound dressing that could effectively inhibit the expression of MMP-9 offers significant clinical translation for diabetic wound healing. Herein, a hybrid hydrogel dressing was developed for localized and sustained delivery of MMP-9 siRNA (siMMP-9). siMMP-9 was complexed with Gly-TETA (GT), the GT/siMMP9 complex was then loaded into a...
Paper Details
Title
Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing
Published Date
May 5, 2021
Journal
Volume
19
Issue
1
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