Internal medicine

Cell

Disease

Peptidyl-Dipeptidase A

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Blood pressure

Biology

Endocrinology

Outbreak

Virology

Renin–angiotensin system

Angiotensin-converting enzyme 2

2019-20 coronavirus outbreak

Cell biology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Biochemistry

Medicine

Using an infection-permissive human kidney cell line, Yeung et al. show that a soluble form of ACE2 that is cleaved and liberated from the host cell surface mediates SARS-CoV-2 binding and uptake by receptors involved in renin-angiotensin system signaling.

Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system