Experimental Babesia Rossi Infection Induces Hemolytic, Metabolic, and Viral Response Pathways in the Canine Host

Published on Aug 16, 2021
· DOI :10.1186/S12864-021-07889-4
Rachel L. Smith , Amelia Goddard18
Estimated H-index: 18
+ 5 AuthorsHans Ackerman18
Estimated H-index: 18
#1Xiao He (NIH: National Institutes of Health)H-Index: 4
#2Lu Xia (CSU: Central South University)H-Index: 4
Last. Xin-zhuan Su (NIH: National Institutes of Health)H-Index: 73
view all 5 authors...
Type I interferons (IFN-Is) are important cytokines playing critical roles in various infections, autoimmune diseases, and cancer. Studies have also shown that IFN-Is exhibit 'conflicting' roles in malaria parasite infections. Malaria parasites have a complex life cycle with multiple developing stages in two hosts. Both the liver and blood stages of malaria parasites in a vertebrate host stimulate IFN-I responses. IFN-Is have been shown to inhibit liver and blood stage development, to suppress T...
1 CitationsSource
#1Mauro Valentino Paloschi (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 4
#2Jéssica Amaral Lopes (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 3
Last. Juliana P. Zuliani (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 16
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Cr-LAAO, an l-amino acid oxidase isolated from Calloselasma rhodosthoma snake venom, has been demonstrated as a potent stimulus for neutrophil activation and inflammatory mediator production. However, the mechanisms involved in Cr-LAAO induced neutrophil activation has not been well characterized. Here we investigated the mechanisms involved in Cr-LAAO-induced lipid body (also known as lipid droplet) biogenesis and eicosanoid formation in human neutrophils. Using microarray analysis, we show for...
5 CitationsSource
#1Runliu Wu (UTSW: University of Texas Southwestern Medical Center)H-Index: 4
#2Feng Chen (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
Last. Rui Kang (UTSW: University of Texas Southwestern Medical Center)H-Index: 26
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Immunometabolism plays a fundamental role in health and diseases and involves multiple genes and signals. Aconitate decarboxylase 1 (ACOD1; also known as IRG1) is emerging as a regulator of immunometabolism in inflammation and infection. Upregulation of ACOD1 expression occurs in activated immune cells (e.g., macrophages and monocytes) in response to pathogen infection (e.g., bacteria and viruses), pathogen-associated molecular pattern molecules (e.g., LPS), cytokines (e.g., TNF and IFNs), and d...
7 CitationsSource
#1Alischa Henning (University of Pretoria)H-Index: 1
#2Sarah J. Clift (University of Pretoria)H-Index: 13
Last. Andrew L. Leisewitz (University of Pretoria)H-Index: 18
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AIM: To provide useful information based on the macropathology, histopathology and immunohistochemical investigation in the spleens of dogs with Babesia rossi infection. METHODS AND RESULTS: Control spleens were collected from four healthy dogs euthanized for welfare reasons. Nine dogs that died naturally because of a mono-infection with Babesia rossi were selected for the diseased group. One haematoxylin and eosin stained section of splenic tissue from each of the infected and control dogs was ...
2 CitationsSource
#1Brittany A. Riggle (NIH: National Institutes of Health)H-Index: 6
#2Monica ManglaniH-Index: 6
Last. Susan K. Pierce (NIH: National Institutes of Health)H-Index: 22
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BACKGROUNDCerebral malaria (CM) accounts for nearly 400,000 deaths annually in African children. Current dogma suggests that CM results from infected RBC (iRBC) sequestration in the brain microvasculature and resulting sequelae. Therapies targeting these events have been unsuccessful; findings in experimental models suggest that CD8+ T cells drive disease pathogenesis. However, these data have largely been ignored because corroborating evidence in humans is lacking. This work fills a critical ga...
24 CitationsSource
#1Laurent Rénia (Agency for Science, Technology and Research)H-Index: 81
#2Georges E. Grau (USYD: University of Sydney)H-Index: 91
Last. Samuel C. Wassmer (Lond: University of London)H-Index: 21
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Mosquito-transmitted Plasmodium falciparum infection can cause human cerebral malaria (HCM) with high mortality rates. The abundance of infected red blood cells that accumulate in the cerebral vasculature of patients has led to the belief that these brain-sequestered cells solely cause pathogenesis. However, animal models suggest that CD8+ T cells migrate to and accumulate in the brain, directly contributing to experimental cerebral malaria (ECM) mortality. In this issue of the JCI, Riggle et al...
6 CitationsSource
#1Rajiv Kumar (IMS-BHU: Institute of Medical Sciences, Banaras Hindu University)H-Index: 25
#2Patrick T. Bunn (Griffith University)H-Index: 12
Last. Christian R. Engwerda (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 66
view all 31 authors...
Summary Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune responses in some infectious diseases. Here, we identify type I IFNs as major upstream regulators of CD4+ T cells from visceral leishmaniasis (VL) patients. Furthermore, we report that mice deficient in type I IFN signaling have significantly improved control of Leishmania donovani, a causative agent of human VL, associated with enhanced IFNγ but reduced IL-1...
16 CitationsSource
#1Li Qin (Academy of Medical Sciences, United Kingdom)H-Index: 2
#2Yanbo NieH-Index: 2
Last. Kun Ru (Academy of Medical Sciences, United Kingdom)H-Index: 1
view all 7 authors...
Hereditary spherocytosis (HS) is the most common inherited hemolytic anemia characterized by the presence of spherical-shaped erythrocytes on the peripheral blood smear, hemolysis, splenomegaly, jaundice, and gallstones. To date, mutations in at least five genes (ANK1, EPB42, SLC4A1, SPTA1, and SPTB) have been found to be associated with different subtypes of HS. Here, we aim to investigate the presence of novel as well as known mutations in 35 Chinese patients with clinically suspected HS. Whol...
9 CitationsSource
#1Magdalene K. Montgomery (UNSW: University of New South Wales)H-Index: 18
#2Brenna Osborne (UNSW: University of New South Wales)H-Index: 15
Last. Nigel Turner (UNSW: University of New South Wales)H-Index: 58
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Fatty acid receptors have been recognized as important players in glycaemic control. This study is the first to describe a role for the medium-chain fatty acid (MCFA) receptor G-protein–coupled rec...
12 CitationsSource
#1Neeraj K. Sharma (Wake Forest University)H-Index: 16
#2Chia-Chi C. Key (Wake Forest University)H-Index: 4
Last. Swapan K Das (Wake Forest University)H-Index: 30
view all 8 authors...
Insulin resistance (IR) is a harbinger of type 2 diabetes (T2D) and partly determined by genetic factors. However, genetically-regulated mechanisms of IR remain poorly understood. Using gene expression, genotype, and insulin sensitivity data from an African American cohort (AAGMEx), we performed transcript-wide correlation and expression quantitative trait loci (eQTL) analyses to identify IR-correlated cis -regulated transcripts ( cis -eGenes) in adipose tissue. These IR-correlated cis -eGenes w...
6 CitationsSource
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