Acupoint catgut embedding improves senescence in a rat model of ageing by regulating mitophagy via the PINK1 pathway

Published on Mar 1, 2021in Journal of Cellular and Molecular Medicine4.486
· DOI :10.1111/JCMM.16295
Meiling Zhou (SYSU: Sun Yat-sen University), Yumei Yuan + 6 AuthorsHong Zhang (Guangzhou University of Chinese Medicine)
Ageing population is a tough task worldwide, and the aggravating trend of ageing population in China brings enormous pressure to healthcare system. Chinese acupuncture has shown definite anti-ageing effect as arthralgia relief, movement improvement, energy increase and immunity enhancement; however, the mechanisms underlying are far away from illumination. Increasing literature has highlighted the role of alterations in mitochondrial function as a potential central regulator in ageing biology; mitophagy plays a critical role in mitochondrial quality control. In the present study, we demonstrated that acupoint catgut embedding treatment ameliorated ageing-related alterations in appearance, muscle function and spatial memory in rats, reduced degenerated cells in hippocampus, and maintained relatively normal structures in the hippocampus tissue and neurons. These changes were proved to be associated with the regulation of mitochondrial function and autophagic activity. Furthermore, we investigated part of the molecular mechanisms and demonstrated that the PINK1 other than PINK1-Parkin signalling pathway involved in the effects of acupoint catgut embedding, and the imbalancement between mitochondrial fusion and fission and stimulation of mitochondrial biogenesis may aggravate or compensate for impaired mitochondria. The factors act downstream PINK, and the interaction between them for mitochondrial homeostasis in this process remains to be identified.
#1Tingwei XiaH-Index: 3
#2Yue YangH-Index: 3
Last. Yongsong GuoH-Index: 2
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Background: Diabetic gastroparesis (DG) is a common complication to diabetes mellitus (DM). A lot of clinical researches have focused on acupoint catgut embedding for diabetic gastroparesis. However, there is no systematic review and meta-analysis has been conducted. We aim to systematically review the effect of acupoint catgut embedding on diabetic gastroparesis.
4 CitationsSource
#1Yi-qin Wang (Hunan University)H-Index: 1
#2Ling-yu Chen (Hunan University)H-Index: 1
Last. Biao Tang (Hunan University)H-Index: 1
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OBJECTIVE: To observe the effect of acupoint catgut embedding on the expression of nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome, interleukin (IL)-1β and IL-18 in the uterine tissue of primary dysmenorrhea (PD) rats, so as to explore its underlying mechanisms in improving PD. METHODS: Forty female SD rats were randomly divided into control, model, acupoint catgut embedding and medication groups (n=10 in each group). The PD model was established by s...
1 CitationsSource
#1Fu XuH-Index: 1
#2Li-hua XuanH-Index: 2
Last. Xiang WuH-Index: 1
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Objective To investigate the effects and safety of catgut embedding on alleviating insomnia.
7 CitationsSource
Acupoint catgut embedding is a useful therapy for weight management and widely applied in China. This review aimed to systematically evaluate the effects of acupoint catgut embedding on abdominal obesity. We searched the PubMed, Cochrane-Library, Embase, OVID, MEDLINE, ISI (web of science), Wanfang, VIP, CBM, and CNKI for randomized controlled trials that used acupoint catgut embedding to treat abdominal obesity before April 2019 with the language restriction of Chinese and English. The combinat...
30 CitationsSource
#1Ji Yong Jang (University of Pittsburgh)H-Index: 2
#2Arnon Blum (BIU: Bar-Ilan University)H-Index: 20
Last. Toren Finkel (University of Pittsburgh)H-Index: 108
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81 CitationsSource
#1Amandine Grimm (University of Basel)H-Index: 15
#2Anne Eckert (University of Basel)H-Index: 67
Aging is defined as a progressive time-related accumulation of changes responsible for or at least involved in the increased susceptibility to disease and death. The brain seems to be particularly sensitive to the aging process since the appearance of neurodegenerative diseases, including Alzheimer's disease, is exponential with the increasing age. Mitochondria were placed at the center of the ‘free-radical theory of aging’, because these paramount organelles are not only the main producers of e...
158 CitationsSource
Abstract The burden of stroke is high and is continually increasing due to a dramatic growth in the world's elderly population. Novel therapeutic strategies are therefore required. The present study sought to determine the effect of laser acupuncture at GV20 on brain damage, oxidative-status markers in the cerebral cortex, and superoxide dismutase in the mitochondria of an animal model of focal ischemic stroke. Wistar rats, weighing 300–350 g, were divided into the following four groups: (1) con...
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#1Vania GelmettiH-Index: 28
#2Priscilla De Rosa (Casa Sollievo della Sofferenza)H-Index: 2
Last. Enza Maria Valente (UNIPV: University of Pavia)H-Index: 73
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ABSTRACTMitophagy is a highly specialized process to remove dysfunctional or superfluous mitochondria through the macroautophagy/autophagy pathway, aimed at protecting cells from the damage of disordered mitochondrial metabolism and apoptosis induction. PINK1, a neuroprotective protein mutated in autosomal recessive Parkinson disease, has been implicated in the activation of mitophagy by selectively accumulating on depolarized mitochondria, and promoting PARK2/Parkin translocation to them. While...
129 CitationsSource
#1Cedíková M (Charles University in Prague)H-Index: 5
#2P PituleH-Index: 1
Last. Jitka Kuncova (Charles University in Prague)H-Index: 16
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Aging is a multifactorial process influenced by genetic factors, nutrition, and lifestyle. According to mitochondrial theory of aging, mitochondrial dysfunction is widely considered a major contributor to age-related processes. Mitochondria are both the main source and targets of detrimental reactions initiated in association with age-dependent deterioration of the cellular functions. Reactions leading to increased reactive oxygen species generation, mtDNA mutations, and oxidation of mitochondri...
30 CitationsSource
#1Evandro Fei Fang (NIH: National Institutes of Health)H-Index: 37
#2Morten Scheibye-Knudsen (NIH: National Institutes of Health)H-Index: 32
Last. Vilhelm A. Bohr (NIH: National Institutes of Health)H-Index: 119
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Signalling from the nucleus to mitochondria (NM signalling) is crucial for regulating mitochondrial function and ageing. It is initiated by nuclear DNA damage and controls genomic and mitochondrial integrity. Pharmacological modulation of NM signalling holds promise for improving lifespan and healthspan.
169 CitationsSource
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