Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins

Volume: 12, Issue: 1
Published: Mar 2, 2021
Abstract
Many genetic diseases are caused by single-nucleotide polymorphisms. Base editors can correct these mutations at single-nucleotide resolution, but until recently, only allowed for transition edits, addressing four out of twelve possible DNA base substitutions. Here, we develop a class of C:G to G:C Base Editors to create single-base genomic transversions in human cells. Our C:G to G:C Base Editors consist of a nickase-Cas9 fused to a cytidine...
Paper Details
Title
Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins
Published Date
Mar 2, 2021
Volume
12
Issue
1
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