MiT/TFE family members suppress L-leucyl–L-leucine methyl ester-induced cell death

Lysosomes are degradative organelles essential for cell homeostasis. However, various internal and external stimuli, including L-leucyl–L-leucine methyl ester (LLOMe), which is one of the common lysosomotropic agents, permeabilize the lysosomal membrane, leading to lysosome-dependent cell death because of leakage of lysosomal contents to the cytosol. The microphthalmia/transcription factor E (MiT/TFE) family members, which include transcription...