Emerging therapies for amblyopia.

Published on Mar 3, 2021in Seminars in Ophthalmology1.205
· DOI :10.1080/08820538.2021.1893765
Michelle M. Falcone1
Estimated H-index: 1
(Harvard University),
David G. Hunter42
Estimated H-index: 42
(Harvard University),
Eric D. Gaier14
Estimated H-index: 14
(Picower Institute for Learning and Memory)
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Abstract
Traditional therapies to treat amblyopia, such as optical correction or occlusion/penalization of the non-amblyopic eye, are efficacious but are not without limitations such as poor adherence and d...
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18 Citations
References41
Newest
#1Dennis M. Levi (HWNI: Helen Wills Neuroscience Institute)H-Index: 82
Abstract Recent work has transformed our ideas about the neural mechanisms, behavioral consequences and effective therapies for amblyopia. Since the 1700′s, the clinical treatment for amblyopia has consisted of patching or penalizing the strong eye, to force the “lazy” amblyopic eye, to work. This treatment has generally been limited to infants and young children during a sensitive period of development. Over the last 20 years we have learned much about the nature and neural mechanisms underlyin...
10 CitationsSource
#1Zhujun Fu (Nanjing Medical University)H-Index: 7
#2Hao HongH-Index: 1
Last. Hu Liu (Nanjing Medical University)H-Index: 13
view all 6 authors...
Purpose Amblyopia is a leading cause of vision impairment among children and young adults. Individual studies showed significant variations in the prevalence of amblyopia in different regions and age groups. This study is to estimate the global prevalence of amblyopia by pooling its prevalence from the previous studies and to project the number of people affected through 2040. Methods We performed a systematic review and meta-analysis on the prevalence of amblyopia using data published before 20...
12 CitationsSource
#1María B. Coco-Martín (University of Valladolid)H-Index: 6
#2David P. Piñero (University of Alicante)H-Index: 48
Last. Juan F. Arenillas (University of Valladolid)H-Index: 27
view all 8 authors...
In recent years, virtual reality (VR) has emerged as a new safe and effective tool for neurorehabilitation of different childhood and adulthood conditions. VR-based therapies can induce cortical reorganization and promote the activation of different neuronal connections over a wide range of ages, leading to contrasted improvements in motor and functional skills. The use of VR for the visual rehabilitation in amblyopia has been investigated in the last years, with the potential of using serious g...
6 CitationsSource
#1Scott XiaoH-Index: 1
#2Eric D. Gaier (Picower Institute for Learning and Memory)H-Index: 14
Last. David G. HunterH-Index: 42
view all 9 authors...
Given the prevalence of poor adherence to therapy and the biases of self-reporting across healthcare, we hypothesized that an engaging, personalized therapy may improve adherence and treatment outcomes in the home. We tested this hypothesis in the initial indication of amblyopia, a neurodevelopmental disorder for which available treatments are limited by low adherence. We designed a novel digital therapeutic that modifies patient-selected cinematic content in real-time into therapeutic visual in...
11 CitationsSource
#1Stacy L. Pineles (Jules Stein Eye Institute)H-Index: 22
#2Vinay K. Aakalu (UIC: University of Illinois at Chicago)H-Index: 14
Last. Scott R. Lambert (Stanford University)H-Index: 47
view all 8 authors...
Purpose To review the published literature assessing the efficacy of binocular therapy for the treatment of amblyopia compared with standard treatments. Methods Literature searches with no date restrictions and limited to the English language were conducted in January 2018 and updated in April 2019 in the PubMed database and the Cochrane Library database with no restrictions. The search yielded 286 citations, and the full text of 50 articles was reviewed. Twenty articles met the inclusion criter...
8 CitationsSource
#1Lauren Sauvan (CNRS: Centre national de la recherche scientifique)H-Index: 3
#2Natacha Stolowy (CNRS: Centre national de la recherche scientifique)H-Index: 3
Last. Alexandre Reynaud (McGill University)H-Index: 13
view all 7 authors...
Dichoptic movie viewing has been shown to significantly improve visual acuity in amblyopia in children. Moreover, short-term occlusion of the amblyopic eye can transiently increase its contribution to binocular fusion in adults. In this study, we first asked whether dichoptic movie viewing could improve the visual function of amblyopic subjects beyond the critical period. Secondly, we tested if this effect could be enhanced by short-term monocular occlusion of the amblyopic eye. 17 subjects pres...
9 CitationsSource
#1Zhale Rajavi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 10
#2Hamideh Sabbaghi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 7
Last. Bahareh Kheiri (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 7
view all 5 authors...
Abstract Purpose To compare the effect of amblyopia therapy on cases who received interactive binocular treatment (I-BiT™) with those who received standard patching of the dominant eye with placebo I-BiT™. Methods In this randomized clinical trial, 38 unilateral amblyopic children (3–10 years old) were studied. All unilateral amblyopic children who had best corrected visual acuity (BCVA) worse than 0.30 logMAR or a difference of two Snellen lines of BCVA between their two eyes were included, and...
5 CitationsSource
#1Eileen E. Birch (UTSW: University of Texas Southwestern Medical Center)H-Index: 83
#2Reed M. JostH-Index: 13
Last. Joel N. LefflerH-Index: 10
view all 8 authors...
Background Binocular amblyopia treatments promote visual acuity recovery and binocularity by rebalancing the signal strength of dichoptic images. Most require active participation by the amblyopic child to play a game or perform a repetitive visual task. The purpose of this study was to investigate a passive form of binocular treatment with contrast-rebalanced dichoptic movies. Methods A total of 27 amblyopic children, 4-10 years of age, wore polarized glasses to watch 6 contrast-rebalanced dich...
13 CitationsSource
#2Jonathan M. Holmes (Mayo Clinic)H-Index: 68
#3Ruth E. Manny (UH: University of Houston)H-Index: 38
Last. David K. Wallace (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 48
view all 14 authors...
Purpose To compare visual acuity (VA) improvement in children aged 7 to 12 years with amblyopia treated with a binocular iPad game plus continued spectacle correction vs. continued spectacle correction alone. Design Multicenter randomized clinical trial. Participants One hundred thirty-eight participants aged 7 to 12 years with amblyopia (33–72 letters, i.e., approximately 20/200 to 20/40) resulting from strabismus, anisometropia, or both. Participants were required to have at least 16 weeks of ...
37 CitationsSource
#1Eleni Papageorgiou (Yahoo!)H-Index: 14
#2Ioannis Asproudis (UoI: University of Ioannina)H-Index: 16
Last. Irene Gottlob (Leicester Royal Infirmary)H-Index: 37
view all 5 authors...
Purpose The purpose of this review is to provide an update on current management and recent research for amblyopia treatment. Part I will review patching, atropine penalization, and pharmacological treatments. Part II will focus on perceptual learning, video gaming, and binocular dichoptic approaches.
18 CitationsSource
Cited By1
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#1Ming-fai Fong (MIT: Massachusetts Institute of Technology)H-Index: 7
#2Kevin R. Duffy (Dal: Dalhousie University)H-Index: 13
Last. Mark F. Bear (MIT: Massachusetts Institute of Technology)H-Index: 107
view all 5 authors...
Monocular deprivation early in development causes amblyopia, a severe visual impairment. Prognosis is poor if therapy is initiated after an early critical period. However, clinical observations have shown that recovery from amblyopia can occur later in life when the non-deprived (fellow) eye is removed. The traditional interpretation of this finding is that vision is improved by relieving interocular suppression in primary visual cortex. However, an alternative explanation is that elimination of...
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