Activation and Inhibition of Assay-Ready TRPA1 and TRPV Cells: An Automated Patch Clamp Study

Transient Receptor Potential (TRP) channels are widely distributed throughout the mammalian central and peripheral nervous systems. They can be directly activated by ligands, heat or cold and mechano-stimulation, and are important targets in drug discovery for the treatment of pain, respiratory diseases, cancer, immune disorders and others. Here, we studied the responses of TRPA1, TRPV1, TRPV3 and TRPV4 assay-ready and cultured cells activated...