Multifaceted Mechanism of Amicoumacin A Inhibition of Bacterial Translation
Abstract
Amicoumacin A (Ami) halts bacterial growth by inhibiting the ribosome during translation. The Ami binding site locates in the vicinity of the E-site codon of mRNA. However, Ami does not clash with mRNA, rather stabilizes it, which is relatively unusual and implies a unique way of translation inhibition. In this work, we performed a kinetic and thermodynamic investigation of Ami influence on the main steps of polypeptide synthesis. We show that...
Paper Details
Title
Multifaceted Mechanism of Amicoumacin A Inhibition of Bacterial Translation
Published Date
Feb 12, 2021
Journal
Volume
12
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