The genome sequencing of Mycobacterium tuberculosis, the causative organism of tuberculosis, has significantly improved our understanding of the mechanisms that drive the establishment of infection and disease progression. Several clinical strains of M. tuberculosis exhibit SNPs, the implications of which are only beginning to be understood. Here, we examined the impact of a specific polymorphism in PhoR, the sensor kinase of the PhoPR two-component system. Biochemical analysis revealed reduced ...
Last. Yantao Wu(YZU: Yangzhou University)H-Index: 18
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Although classical swine fever virus (CSFV) infection has been reported to induce autophagy, the specific induced mechanism remains unrevealed. Nonstructural protein 5A (NS5A) of CSFV is a multiphosphorylated protein with multiple functions to regulate viral replication and the host cell immune responses. Herein, we demonstrated that CSFV NS5A could induce cellular autophagy and promote viral replication. In the current study, we showed that NS5A expression significantly increased the levels of ...
Arabinogalactans (AGs) are structural polysaccharides of the plant cell wall. A small proportion of the AGs are associated with hemicellulose and pectin. Furthermore, AGs are associated with proteins forming the so-called arabinogalactan proteins (AGPs), which can be found in the plant cell wall or attached through a glycosylphosphatidylinositol (GPI) anchor to the plasma membrane. AGPs are a family of highly glycosylated proteins grouped with cell wall proteins rich in hydroxyproline. These gly...
Last. S. C. Hart(UCM: University of California, Merced)
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The rapidly increasing global population and anthropogenic climate change have created intense pressure on agricultural systems to produce increasingly more food under steadily challenging environmental conditions. Simultaneously, industrial agriculture is negatively affecting natural and agricultural ecosystems due to intensive irrigation and fertilization to fully utilize the potential of high-yielding cultivars. Growth promoting microbes that increase stress tolerance and crop yield could be ...
One highly attended beach of Marseille, France, was monitored hourly on a summer day of July 2018, in order to determine the possible water and sand fecal pollution in parallel with the influx of beach users from 8 am to 8 pm. Fecal indicator bacteria (FIB) were measured, together with four host-associated fecal molecular markers, chosen in order to discriminate the human, dog, horse or gull/seagull origins of the contamination. The antimicrobial resistance (AMR) of bacteria in water and sand wa...
Soil fungi play critical roles in ecosystem processes and are sensitive to global changes. Elevated atmospheric nitrogen (N) deposition has been well documented to impact on fungal diversity and community composition, but how fungal community assembly responds to the duration effects of experimental N addition remains poorly understood. Here, we aimed to investigate the soil fungal community variations and assembly processes under short- (2 years) versus long-term (13 years) exogenous N addition...
Last. Qing Zhang(SCAU: South China Agricultural University)H-Index: 9
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Vanillic acid (VA) is a phenolic acid derivative commonly found in plants and foods, with a pleasant creamy odour and pharmacologic activities, which is hypothesized to help improve silage fermentation. The silage profile of stylo silage ensiled with addition of VA was evaluated. The results showed that VA addition resulted in the decrease of pH value (5.22 vs 4.33), dry matter loss (5.37% vs 2.51% DM) and ammonia-N proportion (14.57% vs 1.51% CP) of stylo silage as well as the increase of lacti...
#1Lun Hu(CAS: Chinese Academy of Sciences)H-Index: 10
#2Xiaojuan Wang(WUT: Wuhan University of Technology)
Last. Zhu-Hong You(NPU: Northwestern Polytechnical University)
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Proteins are one of most significant components in living organism, and their main role in cells is to undertake various physiological functions by interacting with each other. Thus, the prediction of protein-protein interactions (PPIs) is crucial for understanding the molecular basis of biological processes, such as chronic infections. Given the fact that laboratory-based experiments are normally time-consuming and labor-intensive, computational prediction algorithms have become popular at pres...
#1Jiao Zhao(CUMT: China University of Mining and Technology)
#2Jing Ma(CUMT: China University of Mining and Technology)H-Index: 12
Last. Fu Chen(CUMT: China University of Mining and Technology)
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Vegetation reconstruction and restoration is vital to the health of the mine land ecosystem. Different vegetations usually control the colonization and assembling of soil microbes in roots, mediating the biogeochemical cycle and nutrition supply to the soil. To clarify the response of soil microbes to different vegetation reconstruction modes in the mining areas of the Loess Plateau, China, soil bacterial and fungal community structures and functions, as well as key environmental factors were de...