The developmental origin of health and disease highlights the importance of the period of the first 1000 days (from conception to 2 years) of life. In particular, the process of gut microbiota establishment occurs within this time window. Therefore, determinants interfering with neonatal gut establishment may disrupt its physiological functions and potentially lead to negative health outcomes. Antibiotics are among perinatal determinants that can directly or indirectly affect the pattern of gut ...
#1Beth A. Potter(Penn State Erie, The Behrend College)H-Index: 8
Two relevant topics in keeping populations healthy are handwashing and vaccinations. Thus, the service learning project titled “We Are Healthy” campaign was introduced within a microbiology laboratory course with two objectives; our biologists would better understand the importance of these actions by designing activities that engage the student community and to obtain an understanding of the campus community’s behaviors and beliefs concerning these topics. Students designed the campaign to incl...
Biofilms, when formed on medical devices, can cause malfunctions and reduce the efficiency of these devices, thus complicating treatments and serving as a source of infection. The autolysin protein of Staphylococcus epidermidis contributes to its biofilm forming ability, especially on polystyrene surfaces. R2ab and amidase are autolysin protein domains thought to have high affinity to polystyrene surfaces, and they are involved in initial bacterial attachment in S. epidermidis biofilm formation....
Exopolysaccharides (EPSs) are metabolites synthesized and excreted by a variety of microorganisms, including lactic acid bacteria. EPS serve several biological functions such as interactions between bacteria and their environments, protection against hostile conditions including dehydration, the alleviation of the action of toxic compounds (bile salts, hydrolyzing enzymes, lysozyme, gastric and pancreatic enzymes, metal ions, antibiotics), and stresses (changing pH, osmolarity), and evasion of t...
Considerable research has shown that modifications in global temperature regimes can lead to changes in the interactions between soil respiration and the sequestration of C and N into soil organic matter (SOM). We hypothesized that despite the interconnected nature of respiration, net N mineralization, and nitrification processes, that there would be differences in their thermodynamic responses that would affect the composition of inorganic soil N and the potential for retention of N in SOM. To ...
Last. Gangshi Wang(Chinese PLA General Hospital)H-Index: 1
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Efficacy of Helicobacter pylori (H. pylori) eradication therapy has declined due to rapid rises in antibiotic resistance. We investigated how increased temperature affected H. pylori (NCTC 11637) growth and its sensitivity to metronidazole in vitro. We performed transcriptomic profiling using RNA-sequencing to identify differentially expressed genes (DEGs) associated with increased temperature. Transcriptional pathways involved in temperature-driven metronidazole resistance changes were analysed...