FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity
Abstract
Tissue-specific DNA methylation patterns are created by transcription factors that recruit methylation and demethylation enzymes to cis-regulatory elements. To date, it is not known whether transcription factors are needed to continuously maintain methylation profiles in development and mature tissues or whether they only establish these marks during organ development. We queried the role of the pioneer factor FoxA in generating hypomethylated...
Paper Details
Title
FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity
Published Date
Mar 1, 2021
Journal
Volume
56
Issue
5
Pages
602 - 612.e4
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