The Influence of Glycosylation on the Interaction of the Sars-Cov-2 Spike Protein Receptor Binding Domain with Therapeutic Candidates.

Glycosylation is an important posttranslational modification of proteins and it often plays a crucial role in protein efficacy and binding. It also needs to be understood for optimization of recombinant protein expression and function. We develop fully glycosylated computational models of ACE2-Fc fusion proteins which are promising targets for a COVID-19 therapeutic. Also we study heparin which has been reported to interact with the spike...