Abstract PO085: Cryogel-based cancer vaccine to treat acute myeloid leukemia

Acute myeloid leukemia (AML) is a hematopoietic malignancy with limited therapeutic options. Standard-of-care chemotherapy depletes AML cells to induce remission, but often precedes disease relapse. To promote robust and durable immunity against AML, we developed a macroporous cryogel-based vaccine which provided a sustained release of GM-CSF to concentrate dendritic cells (DCs), TLR agonist CpG-ODN, and leukemia antigen. Prophylactic...