Endpoints for Perianal Crohn’s Disease Trials: Past, Present and Future

Since the 1980s, many studies have evaluated the efficacy of therapies to improve the outcomes of patients with perianal Crohn's disease. We performed a systematic review to describe the evolution of endpoints in perianal fistulizing Crohn's disease. Efficacy outcomes, definitions and measurement tools were assessed.Electronic databases were searched up to November 1, 2020. All published randomized placebo-controlled trials enrolling patients...