Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?

Published on Feb 11, 2021in Lung2.584
· DOI :10.1007/S00408-021-00423-Z
Dominic L Sykes2
Estimated H-index: 2
(Castle Hill Hospital),
Luke Holdsworth2
Estimated H-index: 2
(Castle Hill Hospital)
+ 3 AuthorsMichael G. Crooks13
Estimated H-index: 13
(Castle Hill Hospital)
The enduring impact of COVID-19 on patients has been examined in recent studies, leading to the description of Long-COVID. We report the lasting symptom burden of COVID-19 patients from the first wave of the pandemic. All patients with COVID-19 pneumonia discharged from a large teaching hospital trust were offered follow-up. We assessed symptom burden at follow-up using a standardised data collection technique during virtual outpatient clinic appointments. Eighty-six percent of patients reported at least one residual symptom at follow-up. No patients had persistent radiographic abnormalities. The presence of symptoms at follow-up was not associated with the severity of the acute COVID-19 illness. Females were significantly more likely to report residual symptoms including anxiety (p = 0.001), fatigue (p = 0.004), and myalgia (p = 0.022). The presence of long-lasting symptoms is common in COVID-19 patients. We suggest that the phenomenon of Long-COVID may not be directly attributable to the effect of SARS-CoV-2, and believe the biopsychosocial effects of COVID-19 may play a greater role in its aetiology.
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