FBF1 Deficiency Promotes Beiging and Healthy Expansion of White Adipose Tissue

Preadipocytes dynamically produce sensory cilia. However, the role of primary cilia in preadipocyte differentiation and adipose homeostasis remains poorly understood. We previously identified transition fiber component FBF1 as an essential player of the ciliary gate. Here, we established Fbf1tm1a/tm1a mice and discovered that Fbf1tm1a/tm1a mice develop severe obesity but, surprisingly, are not predisposed to adverse metabolic complications....