Jinghua Hu
Mayo Clinic
CiliumFlagellumBasal bodyMembrane proteinKinaseChemistryCiliogenesisMicrotubuleGTPaseAxonemeCaenorhabditis elegansContext (language use)Small GTPaseCiliopathyPhosphatidylinositolCiliary baseCiliopathiesIntraflagellar transportCancer researchTransport proteinSignal transductionBiologyCell biology
28Publications
15H-index
733Citations
Publications 28
Newest
#1Hui Hong (Fudan University)H-Index: 3
#2Huicheng Chen (CAS: Chinese Academy of Sciences)H-Index: 3
Last. Jinghua Hu (Mayo Clinic)H-Index: 15
view all 0 authors...
Coordination of neurite extension with surrounding glia development is critical for neuronal function, but the underlying molecular mechanisms remain poorly understood. Through a genome-wide mutagenesis screen in C. elegans, we identified dyf-4 and daf-6 as two mutants sharing similar defects in dendrite extension. DAF-6 encodes a glia-specific patched-related membrane protein that plays vital roles in glial morphogenesis. We cloned dyf-4 and found that DYF-4 encodes a glia-secreted protein. Fur...
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#1Chuan Chen (Mayo Clinic)H-Index: 1
#2Qingwen Xu (Mayo Clinic)H-Index: 12
Last. Kun Ling (Mayo Clinic)H-Index: 15
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Mutation of ciliopathy protein HYLS1 causes the perinatal lethal hydrolethalus syndrome (HLS), yet the underlying molecular etiology and pathogenesis remain elusive. Here, we reveal unexpected mechanistic insights into the role of mammalian HYLS1 in regulating primary cilia. HYLS1 is recruited to the ciliary base via a direct interaction with the type Iγ phosphatidylinositol 4-phosphate [PI(4)P] 5-kinase (PIPKIγ). HYLS1 activates PIPKIγ by interrupting the autoinhibitory dimerization of PIPKIγ, ...
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#1Chunhua ChenH-Index: 3
Last. Kun Ling
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Although the immune checkpoint role of programmed death ligand 1 (PD-L1) has been established and targeted in cancer immunotherapy, the tumor-intrinsic role of PD-L1 is less appreciated in tumor biology and therapeutics development, partly because of the incomplete mechanistic understanding. Here we demonstrate a potentially novel mechanism by which PD-L1 promotes the epithelial-mesenchymal transition (EMT) in triple-negative breast cancer (TNBC) cells by suppressing the destruction of the EMT t...
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#1Wen-Ting Yang (NTHU: National Tsing Hua University)
#2Shi-Rong Hong (NTHU: National Tsing Hua University)
Last. Yu-Chun Lin (NTHU: National Tsing Hua University)
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Cilia, which either generate coordinated motion or sense environmental cues and transmit corresponding signals to the cell body, are highly conserved hair-like structures that protrude from the cell surface among diverse species. Disruption of ciliary functions leads to numerous human disorders, collectively referred to as ciliopathies. Cilia are mechanically supported by axonemes, which are composed of microtubule doublets. It has been recognized for several decades that tubulins in axonemes un...
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#1Wenjun Lin (SJTU: Shanghai Jiao Tong University)
#2Cheng Qiao (SJTU: Shanghai Jiao Tong University)
Last. Tao Xu (SJTU: Shanghai Jiao Tong University)
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Abstract We previously found that ATP synthases localize to male-specific sensory cilia and control the ciliary response by regulating polycystin signalling in Caenorhabditis elegans. Herein, we discovered that the ciliary localization of ATP synthase is evolutionarily conserved in mammals. We showed that the ATP synthase subunit F1β is colocalized with the cilia marker acetylated α-tubulin in both mammalian renal epithelial cells (MDCK) and normal mouse cholangiocytes (NMCs). Treatment with ATP...
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#1Jinghua Hu (Mayo Clinic)H-Index: 15
#2Peter C. Harris (Mayo Clinic)H-Index: 99
Abstract The major autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2, are wildly expressed at the organ and tissue level. PKD1 encodes polycystin 1 (PC1), a large membrane associated receptor-like protein that can complex with the PKD2 product, PC2. Various cellular locations have been described for both PC1, including the plasma membrane and extracellular vesicles, and PC2, especially the endoplasmic reticulum (ER), but compelling evidence indicates that the primary cili...
4 CitationsSource
#1Hui Hong (CAS: Chinese Academy of Sciences)H-Index: 1
#1Hui Hong (Fudan University)H-Index: 3
Last. Qing Wei (CAS: Chinese Academy of Sciences)H-Index: 13
view all 11 authors...
Coordination of neurite extension with surrounding glia development is critical for neuronal function, but the underlying molecular mechanisms remain poorly understood. Through a genome-wide mutagenesis screen in C. elegans, we identified dyf-4 and daf-6 as two mutants sharing similar defects in dendrite extension. DAF-6 encodes a glia-specific patched-related membrane protein that plays vital roles in glial morphogenesis. We cloned dyf-4 and found that DYF-4 encodes a glia-secreted extracellula...
Source
#1Hui Hong (Fudan University)H-Index: 1
#2Huicheng Chen (CAS: Chinese Academy of Sciences)H-Index: 3
Last. Jinghua HuH-Index: 15
view all 11 authors...
Coordination of neurite extension with surrounding glia development is critical for neuronal function, but the underlying molecular mechanisms remain poorly understood. Through a genome-wide mutagenesis screen in C. elegans, we identified dyf-4 and daf-6 as two mutants sharing similar defects in dendrite extension. DAF-6 encodes a glia-specific patched-related membrane protein that plays vital roles in glial morphogenesis. We cloned dyf-4 and found that DYF-4 encodes a glia-secreted extracellula...
1 CitationsSource
#1Yanan Hou (CAS: Chinese Academy of Sciences)H-Index: 1
#2Zhimao Wu (CAS: Chinese Academy of Sciences)H-Index: 2
Last. Qing Wei (CAS: Chinese Academy of Sciences)H-Index: 13
view all 8 authors...
Cilia and flagella are conserved subcellular organelles, which arise from centrioles and play critical roles in development and reproduction of eukaryotes. Dysfunction of cilia leads to life-threatening ciliopathies. HYLS1 is an evolutionarily conserved centriole protein, which is critical for ciliogenesis, and its mutation causes ciliopathy-hydrolethalus syndrome. However, the molecular function of HYLS1 remains elusive. Here, we investigated the function of HYLS1 in cilia formation using the D...
1 CitationsSource
#1Hao Yan (CAS: Chinese Academy of Sciences)H-Index: 95
#1Hao Yan (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Qing Wei (CAS: Chinese Academy of Sciences)H-Index: 13
view all 8 authors...
Transition fibers (TFs) regulate cilia gating and make the primary cilium a distinct functional entity. However, molecular insights into the biogenesis of a functional cilia gate remain elusive. In a forward genetic screen in Caenorhabditis elegans, we uncover that TALP-3, a homolog of the Joubert syndrome protein TALPID3, is a TF-associated component. Genetic analysis reveals that TALP-3 coordinates with ANKR-26, the homolog of ANKRD26, to orchestrate proper cilia gating. Mechanistically, TALP-...
2 CitationsSource