Original paper
Genomic Features and Classification of Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma
Abstract
Background and Aims Homologous recombination deficiency (HRD) in pancreatic ductal adenocarcinoma (PDAC), remains poorly defined beyond germline (g) alterations in BRCA1, BRCA2, and PALB2. Methods We interrogated whole genome sequencing (WGS) data on 391 patients, including 49 carriers of pathogenic variants (PVs) in gBRCA and PALB2. HRD classifiers were applied to the dataset and included (1) the genomic instability score (GIS) used by Myriad’s...
Paper Details
Title
Genomic Features and Classification of Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma
Published Date
May 1, 2021
Journal
Volume
160
Issue
6
Pages
2119 - 2132.e9
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Notes
History