Potential Mechanisms behind Air Pollution Toxicity: Findings from Real-World Chronic Exposures

Published on Feb 1, 2021in Environmental Health Perspectives9.031
· DOI :10.1289/EHP8877
#1Sabrina Edwards (OHSU: Oregon Health & Science University)H-Index: 1
#2Gang Zhao (OHSU: Oregon Health & Science University)H-Index: 1
Last. Xiaoquan Rao (OHSU: Oregon Health & Science University)H-Index: 1
view all 10 authors...
Background: Traffic-related air pollution (TRAP) is made up of complex mixtures of particulate matter, gases and volatile compounds. However, the effects of TRAP on the cardiopulmonary system in mo...
#1Jos Lelieveld (The Cyprus Institute)H-Index: 106
#2Andrea Pozzer (MPG: Max Planck Society)H-Index: 45
Last. Thomas Münzel (University of Mainz)H-Index: 134
view all 6 authors...
AIMS: Long-term exposure of humans to air pollution enhances the risk of cardiovascular and respiratory diseases. A novel Global Exposure Mortality Model (GEMM) has been derived from many cohort studies, providing much-improved coverage of the exposure to fine particulate matter (PM2.5). We applied the GEMM to assess excess mortality attributable to ambient air pollution on a global scale and compare to other risk factors. METHODS AND RESULTS: We used a data-informed atmospheric model to calcula...
#1Carlyn J. Matz (Health Canada)H-Index: 5
#2Marika Egyed (Health Canada)H-Index: 6
Last. Nigel Edmonds (Health Canada)H-Index: 1
view all 6 authors...
Background Traffic-related air pollution (TRAP) is one of the major sources of exposure in urban areas and has been associated with a wide range of adverse human health effects. Much of the Canadian population is regularly exposed to TRAP as a result of daily activities (e.g., commuting) and a significant portion of the population resides in close proximity to major roadways. The objective of this scoping review is to develop an evidence map of the epidemiological literature of the human health ...
#1Richard T. Burnett (Health Canada)H-Index: 94
#2Hong Chen (Health Canada)H-Index: 32
Last. Scott Weichenthal (McGill University)H-Index: 56
view all 54 authors...
Exposure to ambient fine particulate matter (PM2.5) is a major global health concern. Quantitative estimates of attributable mortality are based on disease-specific hazard ratio models that incorporate risk information from multiple PM2.5 sources (outdoor and indoor air pollution from use of solid fuels and secondhand and active smoking), requiring assumptions about equivalent exposure and toxicity. We relax these contentious assumptions by constructing a PM2.5-mortality hazard ratio function ba...
#1Rui Ding (ZJU: Zhejiang University)H-Index: 3
#2Yongtang Jin (ZJU: Zhejiang University)H-Index: 3
Last. Yinchun Xu (ZJU: Zhejiang University)H-Index: 3
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Abstract Traffic-related air pollution (TRAP) has been acknowledged as a potential risk factor for numerous respiratory disorders including lung cancer; however, the exact mechanisms involved are still unclear. Here we investigated the effects of TRAP exposure on the H3K9 acetylation in rats. The exposure was performed in both spring and autumn with identical study procedures. In each season, 48 healthy Wistar rats were exposed to different levels of TRAP for 4 h, 7 d, 14 d, and 28 d, respective...
#1Jan EmmerechtsH-Index: 13
#2Vanessa De VooghtH-Index: 18
Last. Marc HoylaertsH-Index: 77
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Epidemiological studies indicate that elderly persons are particularly susceptible to the cardiovascular health complications of air pollution, but pathophysiological mechanisms behind the increased susceptibility remain unclear. Therefore, we investigated how continuous traffic-related air pollution exposure affects haemostasis parameters in young and old mice. Young (10 weeks) and old (20 months) mice were placed in an urban roadside tunnel or in a clean environment for 25 or 26 days and marke...
#1Loren E. Wold (The Research Institute at Nationwide Children's Hospital)H-Index: 36
#2Zhekang YingH-Index: 26
Last. Sanjay RajagopalanH-Index: 85
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Background—Air pollution is a pervasive environmental health hazard that occurs over a lifetime of exposure in individuals from many industrialized societies. However, studies have focused primarily on exposure durations that correspond to only a portion of the lifespan. We therefore tested the hypothesis that exposure over a considerable portion of the lifespan would induce maladaptive cardiovascular responses. Methods and Results—C57BL/6 male mice were exposed to concentrated ambient particles...
#1Britt-Marie Larsson (KI: Karolinska Institutet)H-Index: 18
#2Johan Grunewald (KI: Karolinska Institutet)H-Index: 63
Last. Magnus Svartengren (KI: Karolinska Institutet)H-Index: 55
view all 7 authors...
Ambient air pollution is a contributing factor to respiratory morbidity and mortality and asthmatics are a particularly vulnerable population. The aim of the study was to investigate whether acute ...
#1B-M Larsson (KI: Karolinska Institutet)H-Index: 2
#2Maria SehlstedtH-Index: 8
Last. Magnus SvartengrenH-Index: 55
view all 9 authors...
Traffic-related air pollution is associated with adverse respiratory effects. The aim of the present study was to investigate whether exposure to air pollution in a road tunnel causes airway inflam ...
#1Magnus Svartengren (KI: Karolinska Institutet)H-Index: 55
#2V Strand (KI: Karolinska Institutet)H-Index: 6
Last. Göran Pershagen (KI: Karolinska Institutet)H-Index: 115
view all 5 authors...
The aim of this study was to assess whether air pollution in road tunnels would promote asthmatic reactions in persons with mild allergic asthma. Twenty volunteers with mild allergic asthma were exposed, inside a car, for 30 min in a Stockholm city road tunnel. As a control, the subjects were exposed to much lower pollution levels in a suburban area. Four hours after the exposure, the subjects inhaled a low dose of allergen. Asthmatic reaction during the early phase was measured as the increase ...
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