Integrin receptor mediated pH-responsive nano-hydrogel based on histidine-modified poly(aminoethyl methacrylamide) as targeted cisplatin delivery system

The aim of this project was to synthesize a novel nano-hydrogel (NH) and application of this nanomaterial to targeted delivery of cisplatin. The nano-hydrogel (NH) based on random copolymerization of aminoethyl methacrylamide cross-linked with polyethylene glycol dimethacrylate, was fabricated by reversible addition-fragmentation chain transfer method. l-histidine was conjugated to the backbone of the prepared structure. Then, the complexation...