Plasma Citrate and Succinate Are Associated With Neurocognitive Impairment in Older People With HIV.
Abstract
Neurocognitive impairment (NCI) is associated with monocyte activation in people with HIV (PWH). Activated monocytes increase glycolysis, reduce oxidative phosphorylation, and accumulate citrate and succinate, tricarboxylic acid (TCA) cycle metabolites that promote inflammation-this metabolic shift may contribute to NCI and slowed gait speed in PWH.Plasma citrate and succinate were assayed by liquid chromatography-mass spectrometry from 957...
Paper Details
Title
Plasma Citrate and Succinate Are Associated With Neurocognitive Impairment in Older People With HIV.
Published Date
Aug 2, 2021
Journal
Volume
73
Issue
3
Pages
e765 - e772
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