Fermentative High-Level Production of 5-Hydroxyvaleric Acid by Metabolically Engineered Corynebacterium glutamicum

We report metabolic engineering of Corynebacterium glutamicum (C. glutamicum) for high-level production of 5-hydroxyvaleric acid (5-HV), an important C5 platform chemical covering a wide range of industrial applications, using glucose as a sole carbon source. To derive 5-HV, an artificial 5-HV biosynthesis pathway, composed of the first three reaction steps of an l-lysine catabolic pathway via 5-aminovaleramide along with a subsequent...