Proliferative polyploid cells give rise to tumors via ploidy reduction

Volume: 12, Issue: 1
Published: Jan 28, 2021
Abstract
Polyploidy is a hallmark of cancer, and closely related to chromosomal instability involved in cancer progression. Importantly, polyploid cells also exist in some normal tissues. Polyploid hepatocytes proliferate and dynamically reduce their ploidy during liver regeneration. This raises the question whether proliferating polyploids are prone to cancer via chromosome missegregation during mitosis and/or ploidy reduction. Conversely polyploids...
Paper Details
Title
Proliferative polyploid cells give rise to tumors via ploidy reduction
Published Date
Jan 28, 2021
Volume
12
Issue
1
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