Recent advances and discoveries in the mechanisms and functions of CAR T cells

Volume: 21, Issue: 3, Pages: 145 - 161
Published: Jan 22, 2021
Abstract
This Review discusses the major advances and changes made over the past 3 years to our understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the field has gained insight into how various molecular modules of the CAR influence signalling and function. We report on mechanisms of toxicity and resistance as well as novel engineering and pharmaceutical interventions to overcome these challenges. Looking forward, we...
Paper Details
Title
Recent advances and discoveries in the mechanisms and functions of CAR T cells
Published Date
Jan 22, 2021
Volume
21
Issue
3
Pages
145 - 161
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