Core–shell-Structured ZIF-8@PDA-HA with Controllable Zinc Ion Release and Superior Bioactivity for Improving a Poly-l-lactic Acid Scaffold

Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles are able to act as effective reinforcements to enhance the overall performance of a poly-l-lactic acid (PLLA) scaffold due to its interface compatibility and natural degradability. Nevertheless, the fast degradation of ZIF-8 would release excessive zinc ions, which produces adverse effects on natural cell growth. In this study, a core–shell-structured nanoparticle, in which ZIF served as a...