Pharmacological and Antioxidant Activities of Rhus coriaria L. (Sumac).

Published on Jan 8, 2021in Antioxidants5.014
· DOI :10.3390/ANTIOX10010073
Halima Alsamri3
Estimated H-index: 3
(United Arab Emirates University),
Khawlah Athamneh6
Estimated H-index: 6
(United Arab Emirates University)
+ 2 AuthorsRabah Iratni21
Estimated H-index: 21
(United Arab Emirates University)
Sources
Abstract
Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, ulcer, and eye inflammation. This plant is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic compounds, organic acids, and many others. By virtue of its bioactive, Rhus coriaria possesses powerful antioxidant capacities that have ameliorative and therapeutic benefits for many common diseases including cardiovascular disease, diabetes, and cancer. This review describes the phytochemical properties of R. coriaria and then focuses on the potent antioxidant capacities of sumac. We then dissect the cellular and molecular mechanisms of sumac’s action in modulating many pathophysiological instigators. We show how accumulating evidence supports the antibacterial, antinociceptive, antidiabetic, cardioprotective, neuroprotective, and anticancer effects of this plant, especially that toxicity studies show that sumac is very safe to consume by humans and has little toxicity. Taken together, the findings we summarize here support the utilization of this plant as an attractive target for drug discovery.
📖 Papers frequently viewed together
2 Citations
20163.27Molecules
5 Authors (Gulay Ozkan, ..., Esra Capanoglu)
39 Citations
References144
Newest
#1Taygun Timocin (Çukurova University)H-Index: 4
#2Mehmet Arslan (RMIT: RMIT University)H-Index: 5
Last. Hasan Basri Ila (Çukurova University)H-Index: 7
view all 3 authors...
AbstractRhus coriaria has been important in the treatment of many diseases in traditional use. In this content, the genotoxic, antigenotoxic, and oxidative stress effects of methanol extract of R. ...
3 CitationsSource
#1Dariusz Dziki (University of Life Sciences in Lublin)H-Index: 25
#2Grażyna Cacak-Pietrzak (Warsaw University of Life Sciences)H-Index: 9
Last. Danuta Sugier (University of Life Sciences in Lublin)H-Index: 10
view all 7 authors...
Abstract Physical, sensory and antioxidant properties of wheat bread enriched with sumac flour (SF) with normal and reduced amounts of salt were investigated. SF was added to replace wheat flour at a proportion of 1, 2, 3, 4 and 5 g/100 g. Furthermore, the breads were prepared with normal and reduced amounts of salt (1.5 and 0.5 g/100 g, respectively). The incorporation of SF led to a decrease in bread volume and an increase in crumb hardness, especially when it was added in an amount of more th...
2 CitationsSource
Background Vascular smooth muscle cell (VSMC) migration is integral in the pathogenesis of atherosclerosis. Sumac (Rhus coriaria) berries are believed to have atheroprotective effects. Therefore, Sumac, which is a rich source of tannin antioxidants, was tested for its capacity to inhibit VSMC migratory activity.
36 CitationsSource
#1Tian-Tian Liu (Ministry of Education)H-Index: 1
#1Tian-Tian Liu (Ha Tai: Xiamen University)H-Index: 1
Last. Yan Shi (Ministry of Education)H-Index: 1
view all 4 authors...
Abstract With the rapid increase in the population of obese individuals, obesity has become a global problem. Many kinds of chronic metabolic diseases easily caused by obesity have received increasing attention from researchers. People are also striving to find various safe and effective treatment methods as well as anti-obesity medicines. Pancreatic lipase (PL) inhibitors have received substantial attention from researchers in recent years, and PL inhibitors from natural products have attracted...
16 CitationsSource
#1Turgut Taskin (Marmara University)H-Index: 6
#2Murat Dogan (Cumhuriyet University)H-Index: 1
Last. Ismail Senkardes (Marmara University)H-Index: 7
view all 4 authors...
Abstract Micromeria fruticosa spp. brachycalyx species (Lamiaceae) is used as a spice and flavoring agent. Rhus coriaria (Sumac) is widely used both spice and medicinally. In this study, antioxidant, anti-urease, anticholinesterase, anti-proliferative and calcium oxalate anti-crystallization activities of different extracts from M. fruticosa spp. brachycalyx aerial parts and R. coriaria leaves were investigated. Besides, the phytochemical content of these species was analyzed qualitatively and q...
2 CitationsSource
#1Shiva Roshankhah (Kermanshah University of Medical Sciences)H-Index: 13
#2Mohammadreza Gholami (Kermanshah University of Medical Sciences)H-Index: 11
Last. Mohammad Reza Salahshoor (Kermanshah University of Medical Sciences)H-Index: 17
view all 3 authors...
Morphine is the most common analgesic drug that is widely used in post-operative interventions. This drug causes free radical accumulation leading to spermatogenesis failure. Antioxidant agents like Sumach (Rhus coriaria) neutralize cellular free radicals. In this study, the properties of antioxidative, modulative of inflammatory cytokines, and apoptotic genes following Sumach extract administration on morphine-induced fertility destruction in male Wistar rats was evaluated. Sixty-four animals w...
1 CitationsSource
#1Emma Nozza (University of Milan)H-Index: 1
#2Gloria Melzi (University of Milan)H-Index: 4
Last. Enrico Sangiovanni (University of Milan)H-Index: 16
view all 8 authors...
Rhus coriaria L. (sumac) is a small plant widely diffused in the Mediterranean region. Its fruit are often consumed as a spice but are also present in traditional medicine of several countries. Recently, interest in this plant has increased and many scientific works reported its beneficial effects including antioxidant and anti-inflammatory properties. Plant extracts can be successfully used against ultraviolet rays, which are able to reach and damage the human skin; however, sumac extracts were...
5 CitationsSource
#1Amir Ahmadian (IAU: Islamic Azad University)H-Index: 3
#2Alireza Seidavi (IAU: Islamic Azad University)H-Index: 16
Last. Clive J. C. Phillips (UQ: University of Queensland)H-Index: 44
view all 3 authors...
Alternatives to antibiotics as growth promoters for broilers could reduce bacterial resistance to antibiotics, while at the same time maintaining growth and improving carcass composition. We investigated the benefits of adding the medicinal plants sumac and thyme at 1, 2 or 3% of the diet for male Ross broiler chicks, with four replicates of ten birds in each treatment group and a Control. Feed intake was reduced for chickens fed the sumac supplements, and, at the two higher doses, defeathered b...
3 CitationsSource
#1Zaha A. Elagbar (Al-Ahliyya Amman University)H-Index: 5
#2Ashok K. Shakya (Al-Ahliyya Amman University)H-Index: 13
Last. Hala I. Al-Jaber (Al-Balqa` Applied University)H-Index: 12
view all 4 authors...
Rhus coriaria L. (Anacardiaceae), sumac, is a common condiment, appetizer and souring agent in the Mediterranean region that has a long history in traditional medicine. R. coriaria has been prescribed for the treatment of many ailments including diarrhea, ulcer, hemorrhoids, hemorrhage, wound healing, hematemesis, and eye ailments like ophthalmia and conjunctivitis. The plant is also used as diuresis, antimicrobial, abortifacient and as a stomach tonic. Sumac is known to be rich in different cla...
2 CitationsSource
#1Khawlah Athamneh (United Arab Emirates University)H-Index: 6
#2Aysha Hamad Alneyadi (United Arab Emirates University)H-Index: 5
Last. Rabah Iratni (United Arab Emirates University)H-Index: 21
view all 9 authors...
Colorectal cancer (CRC) is the third most common type of cancer in terms of incidence and mortality worldwide. Here we have investigated the anti-colon cancer potential of Origanum majorana essential oil (OMEO) and its underlying mechanisms of action. We showed that OMEO significantly inhibited the cellular viability and colony growth of human HT-29 colorectal cancer cells. OMEO induced protective autophagy, associated with downregulation of the mTOR/p70S6K pathway, and activated caspase-8 and c...
4 CitationsSource
Cited By2
Newest
#1Sami A. Gabr (KSU: King Saud University)H-Index: 2
#1Sami A Gabr (KSU: King Saud University)H-Index: 2
Last. Ahmad H. Alghadir (KSU: King Saud University)H-Index: 21
view all 2 authors...
Therapeutic strategies of plant origin are a better choice as both dietary plant products or its isolated active constituents against the development and progression of cancer. This study aims to evaluate the anticancer activity of sumac (Rhus coriaria) against different human cancer MCF-7, PC-3, and SKOV3cell lines. In addition, the study tries to explore a prospective mechanism of action, assessment of in vitro enzyme-inhibitory capacity of sumac extract against hCA I, II, IX and XII. In this ...
Source
#1Abraham M. Abraham (University of Marburg)H-Index: 3
#2Camilo Quintero (UdeA: University of Antioquia)H-Index: 1
Last. Cornelia M. Keck (University of Marburg)H-Index: 31
view all 5 authors...
Oxidative stress diseases are usually treated or prevented by using antioxidants from natural or artificial sources. However, as a sustainable source of phytochemicals, plants got a renewed interest in obtaining their active agents using green extraction technologies, i.e., sustainable extraction techniques that reduce energy consumption, use renewable sources and result in less post-extraction wastes. The high-pressure homogenization (HPH) technique was introduced into the food industry since i...
Source
#1Yousery E. Sherif (Mansoura University)H-Index: 9
#2Sami A Gabr (KSU: King Saud University)H-Index: 2
Last. Rayan Alansari (Taibah University)
view all 5 authors...
Background. The outbreak of coronavirus disease 2019 (COVID-19) induced by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in China and spread to cover the entire world with an ongoing pandemic. The magnitude of the situation and the fast spread of the new and deadly virus, as well as the lack of specific treatment, led to a focus on research to discover new therapeutic agents. Aim. In this study, we explore the potential inhibitory effects of some a...
Source