Internal medicine

Pediatrics

Bronchopulmonary dysplasia

Biology

Cardiology

Surgery

Coarctation of the aorta

Pulmonary artery

Gestational age

Left pulmonary artery

Ductus arteriosus

Low birth weight

Pregnancy

Aorta

Stenosis

Genetics

Birth weight

Medicine

Frontiers in Pediatrics

Background: The aim of this study was to describe our experience with transcatheter device closure of patent ductus arteriosus (PDA) in symptomatic low-birth-weight premature infants. Methods: We performed a retrospective study of infants born with a birth body weight of &amp;lt; 2,000 g and admitted to National Cheng Kung University Hospital from September 2014 to December 2019. Basic demographic and clinical information as well as echocardiographic and angiographic data were recorded. Results: Twenty-five premature infants (11 boys and 14 girls) born at gestational ages ranging between 22 and 35 weeks (mean, 25 weeks) were identified. The mean age at procedure was 34.5 ± 5.5 days, and the mean weight was 1,209 ± 94 g (range, 478–1,980 g). The mean diameter of the PDA was 3.4 ± 0.2 mm (range, 2.0–5.4 mm). The following devices were used in this study: Amplatzer Ductal Occluder II additional size ( n = 20), Amplatzer Vascular Plug I ( n = 1), and Amplatzer Vascular Plug II ( n = 4). Complete closure was achieved in all patients. The mean follow-up period was 30.1 ± 17.3 months (range, 6–68 months). In total, 3 patients had left pulmonary artery (LPA) stenosis and 1 patient had coarctation of the aorta during the follow-up period. Younger procedure age and smaller procedure body weight were significantly associated with these obstructions. Conclusions: Performing transcatheter PDA closure in symptomatic premature infants weighing more than 478 g is feasible using currently available devices; moreover, the procedure serves as an alternative to surgery.

Transcatheter Closure of Patent Ductus Arteriosus in Premature Infants With Very Low Birth Weight