Frontiers in Pediatrics
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Despite steadily growing numbers of children diagnosed with autism spectrum disorders (ASD), causative treatment is unavailable. Recently, biological cell therapies involving pluripotent cells have raised hopes towards sustained beneficial outcome. We herein report data of four children diagnosed with ASD, who were treated with autologous, bone marrow (BM)-derived, intrathecally and simultaneously intravenously applied, point-of-care stem cell transplant (SCT). The three boys and one girl receiv...
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#1Antonio Marzollo (UNIPD: University of Padua)H-Index: 8
#2Silvia Bresolin (UNIPD: University of Padua)H-Index: 15
Last. Giorgio PerilongoH-Index: 51
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Nodular Lymphoid Hyperplasia (NLH) is a lymphoproliferative disease caused by non-clonal expansion of lymphoid cells in the gut mucosa. Little is known about the pathogenesis of NLH which is often disregarded as an insignificant or para-physiologic phenomenon. We present the case of a girl with isolated diffuse NLH (extending from the stomach to the rectum) caused by Activated PI3K-delta syndrome (APDS) due to the novel p.Glu525Gly variant in PIK3CD. The gain-of-function effect of the variant wa...
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#1Peiyuan Huang (Guangzhou Medical University)H-Index: 1
#2Feng-Juan Zhou (Guangzhou Medical University)H-Index: 1
Last. Antoine Guedeney (University of Paris)H-Index: 20
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Aim: To investigate the association between the experience of the coronavirus disease 2019 (COVID-19) pandemic and neurodevelopment of six-month-old and one-year-old children and explore the differences in the association by birth order. Methods: This comparison study was embedded in the Born in Guangzhou Cohort Study in China. The exposed group included 546 six-month-old and 285 one-year-old children who attended neurodevelopment assessments between March 1 and May 15, 2020, and the non-exposed...
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Last. Ying Li (Capital Medical University)H-Index: 1
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#1Jeonghee ShinH-Index: 5
#2Jin A LeeH-Index: 16
Last. Byung Min ChoiH-Index: 14
view all 5 authors...
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Neonatal bloodspot screening (NBS) aims to detect treatable disorders in newborns. The number of conditions included in the screening is expanding through technological and therapeutic developments, which can result in health gain for more newborns. NBS expansion, however, also poses healthcare, ethical and societal challenges. This qualitative study explores a multi-stakeholders’ perspective on current and future expansions of NBS. Semi-structured interviews were conducted with 22 Dutch profess...
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#1Saritha Ranabothu (University of Arkansas for Medical Sciences)H-Index: 6
#2Clare C. Brown (University of Arkansas for Medical Sciences)H-Index: 3
Last. Parthak Prodhan (University of Arkansas for Medical Sciences)H-Index: 28
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Background: Hemolytic uremic syndrome (HUS) is a complex disease with multi-organ involvement. Eculizumab therapy is recommended for the treatment of atypical hemolytic uremic syndrome (aHUS). However, there are few studies evaluating eculizumab therapy among children with HUS. The primary objectives of the study were to describe and identify factors associated with eculizumab therapy in children with HUS. Design/Methods: This large, retrospective, multi-center, cohort study used the Pediatric H...
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#1Shujing Han (Capital Medical University)H-Index: 8
#2Qiaoru Zhang (Capital Medical University)
Last. Ya-juan Wang (Boston Children's Hospital)
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Background: The neonatal period is a critical period for the establishment of the intestinal microbial community. Antibiotics can change the composition of gut microbiota. Methods: Fecal samples were collected from 14 patients with pneumonia and 14 patients with meningitis before and after antibiotics treatment, and fecal samples from 5 healthy neonates at 14th, 21th days after birth were collected as well. DNA of fecal samples was extracted and PCR amplification was performed targeting V3-V4 va...
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#1Daniel Mclennan (MCW: Medical College of Wisconsin)
#2Elyan C. Ruiz Solano (MCW: Medical College of Wisconsin)
Last. Edward C. Kirkpatrick (MCW: Medical College of Wisconsin)H-Index: 6
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Pulmonary Vein Stenosis (PVS) is a rare disease with a prevalence of around 1.7 cases per 100000 children under 2 years old. Treatment options for this disease have not provided great results and pathophysiology of this condition is still poorly understood. Here, we will review the history of PVS including diagnostic tools and treatments, the current management approach, and what the future holds for this devastating disease
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