Nanoscopic Dynamics Dictate the Phase Separation Behavior of Intrinsically Disordered Proteins

Many intrinsically disordered proteins (IDPs) in nature may undergo liquid–liquid phase separation to assemble membraneless organelles with varied liquid-like properties and stability/dynamics. While solubility changes underlie these properties, little is known about hydration dynamics in phase-separating IDPs. Here, by studying IDP polymers of similar composition but distinct liquid-like dynamics and stability upon separation, namely, thermal...