Metabolic adaptation in hypoxia and cancer

Volume: 502, Pages: 133 - 142
Published: Apr 1, 2021
The ability of tumor cells to adapt to changes in oxygen tension is essential for tumor development. Low oxygen concentration influences cellular metabolism and, thus, affects proliferation, migration, and invasion. A focal point of the cell's adaptation to hypoxia is the transcription factor HIF1α (hypoxia-inducible factor 1 alpha), which affects the expression of specific gene networks involved in cellular energetics and metabolism. This...
Paper Details
Metabolic adaptation in hypoxia and cancer
Published Date
Apr 1, 2021
133 - 142
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