New phenylpropanoid-conjugated pentacyclic triterpenoids from the whole plants of Leptopus lolonum with their antiproliferative activities on cancer cells.
Abstract Most of Euphorbiaceae plants are considered as folk medicinal plants because of their various pharmacological effects. However, there are eight Leptopus genus plants which belong to Euphorbiaceae have never be investigated. Thus, four Leptopus genus plants were collected to study their chemical constituents and pharmacological activities. In the present work, the cytotoxicities of the extracts of four Leptopus genus plants were evaluated before phytochemical experiments. And nine new phenylpropanoid-conjugated pentacyclic triterpenoids, along with twenty-two known compounds were isolated from the whole plants of Leptopus lolonum. The structures of these new compounds were unequivocally elucidated by HRESIMS and 1D/2D NMR data. All triterpenoids were screened for their cytotoxicities against four cancer cell lines including HepG2, MCF-7, A549 and HeLa. Among these isolates, the triterpenoid with a phenylpropanoid unit showed increasing cytotoxicity on cancer cells, which suggested the importance of the phenylpropanoid moiety.
#1Hui Xiong(Heilongjiang University of Chinese Medicine)H-Index: 1
#2Aihua Zhang(Heilongjiang University of Chinese Medicine)H-Index: 62
Last. Xi-jun Wang(MUST: Macau University of Science and Technology)H-Index: 19
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Abstract Background Quality control of traditional Chinese medicine (TCM) has always been a hot issue to TCM. However, due to the complexity of TCM ingredients, the current quality standards of TCM have problems that are difficult to guarantee clinical efficacy. American ginseng, the dried roots of Pawajc quinquefolium L. (Araliaceae), is a valuable herbal medicine due to various pharmacological effects and huge health benefit, which are associated with numerous active ingredients such as ginsen...
Last. Jih-Jung Chen(PRC: China Medical University (PRC))H-Index: 29
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Abstract Four undescribed alkaloids, 7-ethoxy-6-methoxy-2-methylisoquinolin-1(2H)-one, 7,8-dihydroxy-6-methoxy-2-methylisoquinolin-1(2H)-one, N-formylhernagine, and 5,6-dihydroxy-N-methylphthalimide, were obtained from the root bark of Hernanadia nymphaeifolia, along with fourteen known compounds. The structures of these compounds were determined through spectroscopic and MS analyses. 7,8-Dihydroxy-6-methoxy-2-methylisoquinolin-1(2H)-one, N-formylhernagine, 5,6-dihydroxy-N-methylphthalimide, oxo...
AbstractThirty-three compounds (1–33) were isolated from the rhizomes of Osmunda japonica. Their structures were elucidated on the basis of spectral analysis and identified as ent-kaurene terpenoid...
Last. Da-li Meng(SPU: Shenyang Pharmaceutical University)H-Index: 2
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Abstract 37 compounds mainly including triterpenoids with the quassinoid skeleton and β-carboline alkaloids have been isolated from the roots of Eurycoma longifolia Jack (EL), which has been used as traditional medicine for a long history. It has been demonstrated that the total extracts from EL could significantly inhibit the joint swelling in MSU-induced acute gout arthritis rat model at middle and high doses (P
#1Qiuzhu Dong(CSU: Central South University)H-Index: 2
#2Zhen-Xing Zou(CSU: Central South University)H-Index: 10
Last. Kang-Ping Xu(CSU: Central South University)H-Index: 14
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Abstract Phytochemical investigation of the 70% aqueous EtOH extract of Lycopodium complanatum led to six new polyhydroxy serratene triterpenoids (serrat A-F, 1–6), along with a known analogue (7). Their structures and configurations were elucidated by data analysis of HRESIMS, 1D and 2D NMR, in combination with comparisons of reported experimental spectroscopic data. All the isolates were evaluated cytotoxic activities against HepG2 cells, MCF-7 cells and series human lung cancer cell lines A54...
#1Yan-Ping Liu(Hainan Normal University)H-Index: 8
#2Qing-Long Liu(FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 3
Last. Yan-Hui Fu(FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 8
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Abstract Two new monoterpene indole alkaloids, naucleaoffines A (1) and B (2), together with six known alkaloids (3–8), were isolated from the stems and leaves of Nauclea officinalis. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with the data reported in literature. All isolated compounds were evaluated for their anti-inflammatory activities and anti-HIV-1 activities. Compounds 1–8 exhibited significant inhibi...
Last. Ki-Hyun Kim(SKKU: Sungkyunkwan University)H-Index: 105
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Abstract Poria cocos Wolf confers edible sclerotia also known as ‘Indian bread’ in North America, that have been used for the treatment of various diseases in Asian countries. As part of our ongoing aim to identify biologically new metabolites from Korean edible mushrooms, we investigated the ethanol (EtOH) extract of the sclerotia of P. cocos by applying a comparative LC/MS- and bioassay-based analysis approach, since the EtOH extract reciprocally regulated adipocyte and osteoblast differentiat...
#2Mingna Sun(Guangzhou Medical University)H-Index: 3
Last. Yi Zhou(Guangzhou Medical University)H-Index: 6
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Abstract Expression of CDC28 protein kinase regulatory subunit 1 (Cks1), an adaptor for cyclin-dependent kinases, is tightly regulated at transcriptional and posttranslational levels. Increased expression of Cks1 has been documented to be attributable to cancer progression, chemoresistance, and chemosensitivity. Here we report that ectopic overexpression of Cks1b in human lung cancer cells (Cks1b-OE) induces chemoresistance of the cells to cisplatin (CDDP) and doxorubicin (DOX) through mechanism...
Last. Kang Ro Lee(SKKU: Sungkyunkwan University)H-Index: 37
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Chaenomeles sinensis has been consumed traditionally for the treatment of throat diseases, diarrhea, inflammatory diseases, and dry beriberi. Repeated chromatography of the CHCl3-soluble fraction from the 80% MeOH extract of C. sinensis twigs led to the isolation of three new triterpenoids, sinenic acid A (1), 3β-O-cis-feruloyl-2α,19α-dihydroxyurs-12-en-28-oic acid (2), and 3β-O-cis-caffeoylbetulin (3), together with 20 analogues. The chemical structures of 1–3 were determined using diverse NMR ...
Last. Liya Li(NU: Northeastern University)H-Index: 24
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Abstract In our investigation of the anti-hyperglycaemic constituents of Eugenia jambolana L. (Jamun), one new triterpenoid, 2-O-cis-p-coumaroyl maslinic acid, along with thirteen known triterpenoids were isolated from the fruit ethyl acetate extract. The structures of compounds 1–14 were elucidated on the basis of mass spectrometry and nuclear magnetic resonance analyses. Animal studies demonstrated that the triterpenoid-enriched Jamun fruit extract (TJFE) decreased blood glucose content in C57...
Last. Hui-Yuan Gao(SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract Our present and previous phytochemical investigations on Leptopus lolonum have resulted in the isolation of almost 30 phenylpropanoid-conjugated pentacyclic triterpenoids (PCPTs). During the continuous study on PCPTs, this kind of triterpenoid ester is considered as a natural product with low toxicity because of it’s widely distribution in natural plants and edible fruits including kiwi fruit, durian, jujube, pawpaw, apple and pear. In the present work, we report the isolation, structur...