Bioorganic Chemistry
Papers 5,160
1 page of 516 pages (5,160 results)
#1Maria Saleem Khan (FCC: Forman Christian College)H-Index: 1
Last. Jamshed Iqbal (CIIT: COMSATS University Islamabad)H-Index: 25
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Abstract null null Substitution of hazardous and often harmful organic solvents with “green” and “sustainable” alternative reaction media is always desirous. Ionic liquids (IL) have emerged as valuable and versatile liquids that can replace most organic solvents in a variety of syntheses. However, recently new types of low melting mixtures termed as Deep Eutectic Solvents (DES) have been utilized in organic syntheses. DES are non-volatile in nature, have sufficient thermal stability, and also ha...
#1Cheng Chen (Northwest A&F University)
#1Cheng Chen (MOE: Ministry of Education of the People's Republic of China)H-Index: 10
Last. Jia-Zhu Chigan (MOE: Ministry of Education of the People's Republic of China)H-Index: 2
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Abstract null null The worldwide prevalence of NDM-1-producing Gram-negative pathogens has drastically undermined the clinical efficacy of carbapenems, prompting a need to devise an effective strategy to preserve their clinical value. Here we constructed a focused compound library of dithiocarbamates and systematically evaluated their potential synergistic antibacterial activities combined with copper. SA09-Cu exhibited excellent inhibition against a series of clinical NDM-1-producing carbapenem...
#1Shi Ding (Liaoning University)H-Index: 3
#2Xiaoyong Dong (Liaoning University)
Last. Wenshan Song (Liaoning University)
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Abstract null null On the basis of N-(3-amino-4-methoxyphenyl)acrylamide scaffold, a series of novel compounds containing 3-substitutional-1-methyl-1H-indole, 2-substitutional pyrrole or thiophene moieties were synthesized and their in vitro antiproliferation activities against A549 and H1975 cell lines were evaluated. The results indicated that most of the compounds showed moderate to excellent antitumor activities. Especially, compounds 9a (A549 IC50 = 1.96 μM, H1975 IC50 = 0.095 μM), 17i (A54...
#1Rasha A. Hassan (Cairo University)H-Index: 4
#2Soha Emam (Cairo University)H-Index: 6
Last. Amr Sonousi (University of Hertfordshire)H-Index: 1
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Abstract null null Two series of pyrazoline compounds were designed and synthesized as antiproliferative agents by VEGFR pathway inhibition. All synthesized compounds were screened by the National Cancer Institute (NCI), Bethesda, USA for anticancer activity against 60 human cancer cell lines. Compound 3f exhibited the highest anticancer activity on the ovarian cell line (OVCAR-4) with IC50 = 0.29 μM and on the breast cell line (MDA-MB-468) with IC50 = 0.35 μM. It also exhibited the highest sele...
#2Vesen Atiroğlu (Sakarya University)H-Index: 4
Last. Mahmut Özacar (Sakarya University)H-Index: 41
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Abstract null null Metal-organic structures (MOF), modern extremely proliferous materials consisting of metal ions and organic coordinating molecules, has become a promising biomedical material because of its unusual features, including great surface area, wide pore volume, flexible functionality and superior performance for drug loading. In the current investigation, Gemcitabine Hydrochloride (Gem), an anticancer drug, and Amygdalin (Amy) were loaded into a nanocomposite structure formed from b...
#1Izabela K. Sibilska-Kaminski (UW: University of Wisconsin–Madison)H-Index: 1
#2Adrian Fabisiak (UW: University of Warsaw)H-Index: 4
Last. Hector F. DeLuca (UW: University of Wisconsin–Madison)H-Index: 158
view all 6 authors...
Abstract null null A new series of highly biologically active (20S,22R)-1α,25-dihydroxy-22-methyl- 2-methylene-vitamin D3 analogs, possessing different side chains, have been efficiently prepared as potential agents for medical therapy. Design of these synthetic targets was based on the analysis of the literature data and molecular docking experiments. The synthetic strategy involved Sonogashira coupling of the known A-ring dienyne with the C,D-ring enol triflates, obtained from the correspondin...
#1Umesh Prasad Yadav (All India Institute of Medical Sciences)H-Index: 4
#2Arshad J. Ansari (CURAJ: Central University of Rajasthan)H-Index: 6
Last. Devesh Sawant (CURAJ: Central University of Rajasthan)H-Index: 17
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Abstract null null A series of imido-heterocycle compounds were designed, synthesized, characterized, and evaluated for the anticancer potential using breast (MCF-7 and MDA MB-231), pancreatic (PANC-1), and colon (HCT-116 and HT-29) cancer cell lines and normal cells, while normal cells showed no toxicity. Among the screened compounds, 4h exhibited the best anticancer potential with IC50 values ranging from 1 to 5.5 μM. Compound 4h caused G2/M phase arrest and apoptosis in all the cell lines exc...
#1Qinge Ma (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 10
#2Ye Tang (JUTCM: Jiangxi University of Traditional Chinese Medicine)
Last. Rongrui Wei (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 4
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Abstract null null The fruit of Citrus medica L. var. sarcodactylis Swingle is not only used as a traditional medicinal plant, but also served as a delicious food. Six new (3'→7'')-biflavonoids (1-6), and twelve known biflavonoid derivatives (7-18) were isolated and characterized from the fruits of C. medica L. var. sarcodactylis Swingle for the first time. Their structures were determined by extensive and comprehensive analyzing NMR, HR-ESI-MS, UV, and IR spectral data coupled with the data des...
#1Chengbin Yang (Fudan University)H-Index: 1
#2Mingzhu Lu (Fudan University)H-Index: 1
Last. Yun Ling (Fudan University)H-Index: 19
view all 11 authors...
Abstract null null Breast cancer is the cancer with the highest incidence all over the world. Phosphatidylinositol 3-kinase is an important regulator of intracellular signaling pathways, which is frequently mutated and overexpressed in majority of human breast cancers, and the inhibition of PI3K has been considered as a promising approach for the treatment of the cancer. Here, we report our design and synthesis of new 7-azaindole derivatives as PI3K inhibitors through the scaffold hopping strate...
#1Adinarayana Nandikolla (Birla Institute of Technology and Science, Pilani)H-Index: 4
#2Singireddi Srinivasarao (Birla Institute of Technology and Science, Pilani)H-Index: 6
Last. Kondapalli Venkata Gowri Chandra Sekhar (Birla Institute of Technology and Science, Pilani)H-Index: 12
view all 9 authors...
Abstract null null In the current work, sixteen novel amide derivatives of phenanthridine were designed and synthesized using 9-fluorenone, 4-Methoxy benzyl amine, and alkyl / aryl acids. The characterization of the title compounds was performed using LCMS, elemental analysis, 1HNMR, 13CNMR and single crystal XRD pattern was also developed for compounds A8. All the final analogs were screened in vitro for anti-leishmanial activity against promastigote form of L. infantum strain. Among the tested...
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