Cancer and Stress: Does It Make a Difference to the Patient When These Two Challenges Collide?

Published on Jan 6, 2021in Cancers6.126
· DOI :10.3390/CANCERS13020163
Anem Iftikhar1
Estimated H-index: 1
(Dund.: University of Dundee),
Mohammad Islam3
Estimated H-index: 3
(Dund.: University of Dundee)
+ 2 AuthorsIan R. Ellis19
Estimated H-index: 19
(Dund.: University of Dundee)
Sources
Abstract
A single head and neck Cancer (HNC) is a globally growing challenge associated with significant morbidity and mortality. The diagnosis itself can affect the patients profoundly let alone the complex and disfiguring treatment. The highly important functions of structures of the head and neck such as mastication, speech, aesthetics, identity and social interactions make a cancer diagnosis in this region even more psychologically traumatic. The emotional distress engendered as a result of functional and social disruption is certain to negatively affect health-related quality of life (HRQoL). The key biological responses to stressful events are moderated through the combined action of two systems, the hypothalamus–pituitary–adrenal axis (HPA) which releases glucocorticoids and the sympathetic nervous system (SNS) which releases catecholamines. In acute stress, these hormones help the body to regain homeostasis; however, in chronic stress their increased levels and activation of their receptors may aid in the progression of cancer. Despite ample evidence on the existence of stress in patients diagnosed with HNC, studies looking at the effect of stress on the progression of disease are scarce, compared to other cancers. This review summarises the challenges associated with HNC that make it stressful and describes how stress signalling aids in the progression of cancer. Growing evidence on the relationship between stress and HNC makes it paramount to focus future research towards a better understanding of stress and its effect on head and neck cancer.
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3 CitationsSource
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6 CitationsSource
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Cited By4
Newest
#1Anem Iftikhar (Dund.: University of Dundee)H-Index: 1
#2Mohammad Islam (Dund.: University of Dundee)H-Index: 3
Last. Ian R. Ellis (Dund.: University of Dundee)H-Index: 19
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The COVID-19 pandemic emerged as a largely unexplained outbreak of pneumonia cases, in Wuhan City, China and rapidly spread across the world. By 11th March 2020, WHO declared it as a global pandemic. The resulting restrictions, to contain its spread, demanded a momentous change in the lifestyle of the general population as well as cancer patients. This augmented negative effects on the mental health of patients with head and neck cancer (HNC), who already battle with the stress of cancer diagnos...
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#1Rongsheng Huang (Okayama University)
#2Atsushi Fujimura (Okayama University)H-Index: 13
Last. Atsunori Kamiya (Okayama University)H-Index: 22
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Abstract Malignant peripheral nerve sheath tumor (MPNST), a highly malignant tumor that arises in peripheral nerve tissues, is known to be highly resistant to radiation and chemotherapy. Although there are several reports on genetic mutations and epigenetic changes that define the pathogenesis of MPNST, there is insufficient information regarding the microenvironment that contributes to the malignancy of MPNST. In the present study, we demonstrate that adrenaline increases the cancer stem cell p...
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#1Maryna Koсhuieva (University of Kharkiv)
#2Vasyl Kushnir (University of Kharkiv)
Last. Ivan Hrek (University of Kharkiv)H-Index: 1
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The aim. Assessment of the initial psychological status of men with first diagnosed pulmonary tuberculosis and the study of its associations with the clinical course of the disease. Materials and methods. The study involved 54 men with first diagnosed pulmonary tuberculosis. Patients had a dynamic complex clinical, laboratory and instrumental examination with an assessment of the psychological status according to the State-Trait Anxiety Inventory (STAI) and the Beck Depression Inventory (BDI). R...
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#1Hannah P. PriyankaH-Index: 1
#1Hannah P. PriyankaH-Index: 10
Last. Vasantharekha Ramasamy (SRM University)
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Neuroendocrine-immune homeostasis in health and disease is a tightly regulated bidirectional network that influences predisposition, onset and progression of age-associated disorders. The complexity of interactions among the nervous, endocrine and immune systems necessitates a complete review of all the likely mechanisms by which each individual system can alter neuroendocrine-immune homeostasis and influence the outcome in age and disease. Dysfunctions in this network with age or external/inter...
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