Pharmacological activities and mechanisms of action of Pogostemon cablin Benth: a review

Published on Jan 7, 2021in Chinese Medicine2.96
· DOI :10.1186/S13020-020-00413-Y
Chen Junren1
Estimated H-index: 1
(CDUTCM: Chengdu University of Traditional Chinese Medicine),
Xie Xiao-fang1
Estimated H-index: 1
(CDUTCM: Chengdu University of Traditional Chinese Medicine)
+ 8 AuthorsPeng Cheng2
Estimated H-index: 2
(CDUTCM: Chengdu University of Traditional Chinese Medicine)
Source
Abstract
Patchouli ("Guanghuoxiang") or scientifically known as Pogostemon cablin Benth, belonging to the family Lamiaceae, has been used in traditional Chinse medicine (TCM) since the time of the Eastern Han dynasty. In TCM theory, patchouli can treat colds, nausea, fever, headache, and diarrhea. Various bioactive compounds have been identified in patchouli, including terpenoids, phytosterols, flavonoids, organic acids, lignins, glycosides, alcohols, pyrone, and aldehydes. Among the numerous compounds, patchouli alcohol, β-patchoulene, patchoulene epoxide, pogostone, and pachypodol are of great importance. The pharmacological impacts of these compounds include anti-peptic ulcer effect, antimicrobial effect, anti-oxidative effect, anti-inflammatory effect, effect on ischemia/reperfusion injury, analgesic effect, antitumor effect, antidiabetic effect, anti-hypertensive effect, immunoregulatory effect, and others.For this review, we examined publications from the previous five years collected from PubMed, Web of Science, Springer, and the Chinese National Knowledge Infrastructure databases. This review summarizes the recent progress in phytochemistry, pharmacology, and mechanisms of action and provides a reference for future studies focused on clinical applications of this important plant extract.
References145
Newest
#1Hyeon-Hwa NamH-Index: 6
#2Joong Sun KimH-Index: 23
Last. A Yeong LeeH-Index: 12
view all 9 authors...
Agastache rugosa is used as a Korean traditional medicine to treat gastric diseases. However, the active ingredients and pharmacological targets of A. rugosa are unknown. In this study, we aimed to reveal the pharmacological effects of A. rugosa on gastritis by combining a mice model and a network pharmacology method. The macrophage and gastritis-induced models were used to evaluate the pharmacological effects of A. rugosa. The results show that A. rugosa relieved mucosal damage induced by HCl/E...
3 CitationsSource
#1Fu Peng (Sichuan University)H-Index: 3
#2Liang Xiong (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 15
Last. Cheng Peng (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 32
view all 6 authors...
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that accounts for the largest proportion of breast cancer-related deaths. Thus, it is imperative to search for novel drug candidates with potent anti-TNBC effects. Recent studies suggest that isoliquiritigenin (ISL) can significantly suppress the growth, migration, and invasion of breast cancer cells. We previously synthesized ISL derivatives and found that 3′,4′,5′,4″-Tetramethoxychalcone (TMC) inhibits TNBC cell proliferation t...
11 CitationsSource
#1Xiang Zhang (Sichuan University)H-Index: 36
#2Xiang Li (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 10
Last. Bo Han (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 24
view all 9 authors...
Medium-sized heterocycles exist in a broad spectrum of biologically active natural products and medicinally important synthetic compounds. The construction of medium-sized rings remains challenging, particularly the assembly of different ring sizes from the same type of substrate. Here we report palladium-catalyzed, regiodivergent [5 + 4] and [5 + 2] annulations of vinylethylene carbonates and allylidenemalononitriles. We describe the production of over 50 examples of nine- and seven-membered he...
37 CitationsSource
#1Jihye Lee (UMD: University of Maryland, College Park)H-Index: 5
#2Byung-Whi Kong (UA: University of Arkansas)H-Index: 17
Last. Seong-Ho Lee (UMD: University of Maryland, College Park)H-Index: 35
view all 3 authors...
Abstract Obesity predisposes people to a variety of chronic metabolic diseases. Identification of natural factors that prevent the development of obesity is likely to be the most successful means o...
4 CitationsSource
#1Guohui Zhang (Guangzhou University of Chinese Medicine)H-Index: 3
#2Meijing Liu (Beihang University)H-Index: 4
Last. Zhao Chen (Guangzhou University of Chinese Medicine)H-Index: 2
view all 15 authors...
Abstract Ethnopharmacological relevance Pregnane-X-receptor (PXR) is involved in inflammatory bowel disease (IBD). Patchouli alcohol (PA) has anti-inflammatory effects; however, the mechanisms of PA on IBD remain largely unknown. Aim of the study The aim of the present study was to investigate the anti-inflammatory effect of PA that primarily focused on crosstalk between PA-mediated PXR activation and NF-κB inhibition. Materials and methods We evaluated the anti-inflammatory effect of PA with re...
8 CitationsSource
#1Fu Peng (Sichuan University)H-Index: 1
#2Xiao-Fang Xie (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 11
Last. Cheng Peng (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 32
view all 3 authors...
MicroRNAs, small non-coding RNA molecules, have gained a reputation of the most substantial regulators in gene network with the ability to down-regulate their targets. Accumulating evidence shifted...
15 CitationsSource
#1Dawei Lian (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yifei Xu (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Ping Huang (Guangzhou University of Chinese Medicine)H-Index: 9
view all 7 authors...
Abstract Background Helicobacter pylori infects almost half of the world population and is listed as a type I carcinoma factor since 1994. Pogostemon cablin (Blanco) Benth. (Labiatae) has been used to treat gastro-intestinal diseases for thousands of years in many east Asian countries, and the key ingredient, patchouli alcohol (PA), has been observed to exert anti-H. pylori and anti-urease activities. Purpose We investigated the effect of PA on H. pylori urease and its subsequent influence on ma...
8 CitationsSource
#1Waikit Leong (MUST: Macau University of Science and Technology)H-Index: 4
#2Guoxin Huang (MUST: Macau University of Science and Technology)H-Index: 4
Last. W.L. Wendy Hsiao (MUST: Macau University of Science and Technology)H-Index: 14
view all 10 authors...
Pogostemon cablin (Blanco) Benth (PC) is a Chinese medicinal plant traditionally used for the treatment of gastrointestinal symptoms. To investigate the prebiotic effect of patchouli essential oil (PEO) and its derived compounds through the modulation of gut microbiota (GM). C57BL/6J mice were treated with the PEO and three active components of PEO, i.e. patchouli alcohol (PA), pogostone (PO) and β-patchoulene (β-PAE) for 15 consecutive days. Fecal samples and mucosa were collected for GM biomar...
5 CitationsSource
#1Xue Wu (Guangzhou University of Chinese Medicine)H-Index: 6
#2Nan Xu (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
view all 12 authors...
Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic hepatic disorder worldwide. The earliest stage of NAFLD is simple steatosis, which is characterized by the accumulation of triglycerides in hepatocytes. Inhibition of steatosis is a potential treatment for NAFLD. Patchouli alcohol (PA) is an active component of Pogostemon cablin (Blanco) Benth. (Labiatae), which is a medicinal food in Asia countries and proved to possess hepatoprotective effect. This research aimed to ...
9 CitationsSource
#1Eun-Kyung Kim (Hanyang University)H-Index: 11
#2Ji Hoon Kim (Hanyang University)H-Index: 4
Last. Young Mi Kim (Hanyang University)H-Index: 20
view all 7 authors...
Oxidative stress has been implicated in the pathogenesis of many diseases including chronic liver diseases. Nrf2 is a master transcriptional factor regulating the induction of cellular antioxidant defense systems. Here, the Nrf2-activating effect of the crude methanol extract of dried leaves of Pogostemon cablin Bentham was demonstrated by measuring the antioxidant response element (ARE)-driven luciferase activity and pachypodol, 4′,5-dihydroxy-3,3′,7-trimethoxyflavone, was isolated by bioactivi...
6 CitationsSource
Cited By5
Newest
#1Guan-Ru Chen (CDUTCM: Chengdu University of Traditional Chinese Medicine)
#2Xiao-Fang Xie (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 8
Last. Cheng Peng (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 32
view all 8 authors...
Abstract null null Ethnopharmacological relevance null Essential oil (EO) is the main extract of patchouli and tangerine peel with antiinflammatory, antiulcer, and other functions. However, the efficacy and mechanism of the combination of EO from patchouli and tangerine peel against gastric ulcer (GU) are unclear. null null null Aim of the study null This study aims to reveal the protective effect of the combination of EO from patchouli and tangerine peel against GU in rats, as well as explore t...
Source
#1Chu Wang (Chongqing University)
#2Ying Wang (Chongqing University)
Last. Haiyang Xu (Chongqing University)H-Index: 4
view all 7 authors...
O_LIWe show here that the side chain of pogostone, one of the major components of patchouli oil obtained from Pogostemon cablin and possessing a variety of pharmacological activities, is derived from 4-methylvaleric acid. C_LIO_LIWe also show that 4-methylvaleric acid is produced through the one-carbon - ketoacid elongation pathway with the involvement of the key enzyme 2- isobutylmalate synthase (IBMS), a newly identified enzyme related to isopropylmalate synthase (IPMS) of Leu biosynthesis. C_...
Source
#1M Keerthiraj (IARI: Indian Agricultural Research Institute)
#2Abhishek Mandal (IARI: Indian Agricultural Research Institute)H-Index: 7
Last. Aditi Kundu (IARI: Indian Agricultural Research Institute)H-Index: 11
view all 7 authors...
Root-knot nematode, Meloidogyne incognita is one of the most destructive nematodes worldwide. Essential oils (EOs) are being extensively utilized as eco-benign bionematicides, although the precise mechanism of action remains unclear. Pogostemon cablin Benth. is well-known as "Patchouli". It is native to South East Asia and known for ethno-pharmacological properties. In this study, chemical composition and potential nematicidal effect of EOs hydrodistilled from the leaves of P. cablin grown at th...
Source
Source
Source