Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis
Abstract
•Twist1+/− craniosynostosis mice exhibit elevated ICP and cognitive deficits•Suture MSCs and resorbable biomaterials can support regeneration of patent suture•Suture regeneration normalizes Twist1+/− ICP, skull shape, and cognitive function•Suture regeneration offers a biological solution for craniosynostosis patients Craniosynostosis results from premature fusion of the cranial suture(s), which contain mesenchymal stem cells (MSCs) that are...
Paper Details
Title
Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis
Published Date
Jan 1, 2021
Journal
Volume
184
Issue
1
Pages
243 - 256.e18
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Notes
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