Therapeutic challenges in radiation-induced salivary gland cancers

To give an overview of recent advances in therapeutic approaches of radiation-induced salivary gland cancers (ri-SGCs).Reirradiation with protons and carbon ions demonstrated to be feasible, safe and to offer good local control rates, with the possibility of overcoming radioresistance and dosimetric issues in previously irradiated cancer patients. Chromosomal rearrangements, gene fusions and expression profiles are important to identify specific...