Bioactive dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus.

Published on Mar 1, 2021in Phytochemistry3.044
· DOI :10.1016/J.PHYTOCHEM.2020.112618
Xian-Li Zhou3
Estimated H-index: 3
(GLMU: Guilin Medical University),
Shan-Bin Li (GLMU: Guilin Medical University)+ 7 AuthorsCheng-Qin Liang3
Estimated H-index: 3
(GLMU: Guilin Medical University)
Source
Abstract
Abstract Thirteen undescribed dammarane triterpenoid saponins (cypaliurusides A–M), including eleven seco-dammarane type triterpenoids, were isolated from Cyclocarya paliurus. Each of these compounds has the unique feature of having a monosaccharide attached to C-11, rather than C-12, compared to the same type of saponins found in this plant. The structures of them were determined by comprehensive analysis of 1D, 2D NMR and HRESIMS data. Cypaliuruside J showed significant α-glucosidase inhibitory effect with IC50 value of 2.22 ± 0.13 μM. In addition, Cypaliurusides F and K exhibited modest cytotoxic activities against selected human cancer cell lines in vitro, with IC50 values ranging from 4.61 ± 0.13 to 15.23 ± 3.88 μM.
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Abstract null null Four new C-11 monosaccharide attached dammarane triterpenoid glycosides cypaliurusides S V (1–4), along with nine known dammarane triterpenoid glycosides (5–13) were isolated from a CHCl3-soluble extract of the leaves of Cyclocarya paliurus. All characterized compounds were assayed for their cytotoxicities against HepG2 cells and 10 compounds were evaluated for the agonistic effects on sirtuin1 (SIRT1). The results showed that compounds 1, 5 and 6 were strongly cytotoxic in He...
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