Abstract Thirteen undescribed dammarane triterpenoid saponins (cypaliurusides A–M), including eleven seco-dammarane type triterpenoids, were isolated from Cyclocarya paliurus. Each of these compounds has the unique feature of having a monosaccharide attached to C-11, rather than C-12, compared to the same type of saponins found in this plant. The structures of them were determined by comprehensive analysis of 1D, 2D NMR and HRESIMS data. Cypaliuruside J showed significant α-glucosidase inhibitory effect with IC50 value of 2.22 ± 0.13 μM. In addition, Cypaliurusides F and K exhibited modest cytotoxic activities against selected human cancer cell lines in vitro, with IC50 values ranging from 4.61 ± 0.13 to 15.23 ± 3.88 μM.
#1Tong-Yao Xuan(CSU: Central South University)H-Index: 2
#2Jie Tan(CSU: Central South University)H-Index: 4
Last. Kang-Ping Xu(CSU: Central South University)H-Index: 14
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AbstractThree previously undescribed seco-dammarane triterpenoid glycosides O-Q (1-3) along with two known compounds (4 and 5) were isolated and characterized from the leaves of Cyclocarya paliurus...
#2Chung Sub Kim(SKKU: Sungkyunkwan University)H-Index: 13
Last. Byung Sun Min(CUA: The Catholic University of America)H-Index: 53
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The onion, known as the bulb onion or common onion, is not only key ingredients in many tasty and healthy vegetarian meals but also many traditional medicines. Nine new flavonoids [cepaflavas A, B ...
#2Hong-Tao Zhu(CAS: Chinese Academy of Sciences)H-Index: 16
#3Dong Wang(CAS: Chinese Academy of Sciences)H-Index: 112
Last. Ying-Jun Zhang(CAS: Chinese Academy of Sciences)H-Index: 28
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As the subgroup of flavoalkaloids, N-ethyl-2-pyrrolidinone substituted flavan-3-ols are reported to possess various biological activities that may play important roles in the beneficial healthcare ...
#1Guilin Hu(CAS: Chinese Academy of Sciences)H-Index: 2
#2Ya Gao(CAS: Chinese Academy of Sciences)H-Index: 2
Last. Ming-Hua Qiu(CAS: Chinese Academy of Sciences)H-Index: 26
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Seven new lactam ent-kaurane diterpenoids, cafemide A-G (1-7), were isolated form roasted beans of Coffea arabica. Their structures were elucidated by extensive spectroscopic analysis including 1D, 2D NMR (HSQC, HMBC, 1H-1H COSY, and ROESY), HRESIMS and IR spectra. They were divided into subtype I-III according to the structure. Further, LC-MS/MS based molecular network was used for the excavation of trace lactam type diterpenoids, seven (8-14) subtype II diterpenoids were successfully identifie...
#1Hui-Hui Sun(CSU: Central South University)H-Index: 4
#2Wen-Yan Lv(CSU: Central South University)H-Index: 4
Last. Kang-Ping Xu(CSU: Central South University)H-Index: 14
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Three previously undescribed dammarane triterpenoid glycosides (1-3) along with five known analogues (4-8) were isolated from the leaves of Cyclocarya paliurus. Their structures and configurations were determined on the basis of comprehensive spectroscopic analyses, chemical hydrolysis and DFT GIAO (13)C NMR calculation. All the isolates were evaluated cytotoxic activities against seven human cancer cell lines (MCF-7, PC-3, Du145, NCI-H1975, PC-9, SKVO3 and HepG2). Moreover, compound 4 showed a ...
Abstract Bacopa monnieri (L.) is a reputed medicinal herb in traditional system of medicine of India, where it is used as nervine tonic to sharpen intellect and memory. This review discusses chemical characterization of dammarane triterpenoid glycosides which are well accepted for improvement in memory and for potential pharmacological activities. In addition, this review provides information on the chemical composition of specialized metabolites of B. monnieri and in the formulations by differe...
#1Wei Liu(GXNU: Guangxi Normal University)H-Index: 3
#2Shengping Deng(GXNU: Guangxi Normal University)H-Index: 8
Last. Xishan Huang(GXNU: Guangxi Normal University)H-Index: 4
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ABSTRACT: Cyclocarya paliurus is commonly used for the prevention and treatment of hypertension, diabetes, and inflammation in South China. Although research on the anti-inflammatory effects of C. paliurus leaves has been reported, no active anti-inflammatory compounds have been identified. In the present study, RAW 264.7 cells were used to establish a bioactivity-guided identification model to verify the inhibitory effects of C. paliurus leaves on inflammation and identify the anti-inflammatory ...
AbstractThe chemical composition of Gynostemma burmanicum King ex Chakrav. was investigated for the first time in this study. Nine dammarane glycosides (1‒9) were isolated from the EtOH extract of ...
#1Hui-Hui Sun(CSU: Central South University)H-Index: 4
#2Jie Tan(CSU: Central South University)H-Index: 4
Last. Kang-Ping Xu(CSU: Central South University)H-Index: 14
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Abstract Four new rarely occurred seco-dammarane triterpenoid glycosides (1-4) and four new dammarane triterpenoid glycosides (5-8), along with four known triterpenoids (9-12), were isolated from the 70% ethanol extract of the leaves of Cyclocarya paliurus (family Juglandaceae). Their structures were elucidated by extensive spectroscopic methods, including 1D/2D NMR and HRESIMS data, together with chemical analysis and DFT GIAO 13C NMR calculation. In bioassay, compounds 5-8 significantly increa...
#8Min Zhang(Tianjin University of Science and Technology)H-Index: 18
As a functional food, the unripe fruits of Rubus chingii Hu have been widely used in China for thousands of years. Twenty-five major ellagitannins (ETs) were identified from the unripe fruits, and a novel ellagitannin, chingiitannin A (1), together with four other known ETs (2–5) were isolated and identified by HPLC-QTOF-MS/MS and 2D-NMR. Chingiitannin A showed the highest α-glucosidase and α-amylase inhibitory activities (IC50 2.89 and 4.52 μM, respectively), which occurred in a reversible and ...
Abstract null null Four new C-11 monosaccharide attached dammarane triterpenoid glycosides cypaliurusides S V (1–4), along with nine known dammarane triterpenoid glycosides (5–13) were isolated from a CHCl3-soluble extract of the leaves of Cyclocarya paliurus. All characterized compounds were assayed for their cytotoxicities against HepG2 cells and 10 compounds were evaluated for the agonistic effects on sirtuin1 (SIRT1). The results showed that compounds 1, 5 and 6 were strongly cytotoxic in He...
