Tumor microenvironment

Energy metabolism

Bioinformatics

Biology

Cancer

Endocrinology

Metastasis

Lipid metabolism

Metabolism

Cancer therapy

Cancer research

Genetics

Biochemistry

Cancer cell

The Journal of Experimental Medicine

Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy.

Lipid metabolism and cancer