[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates
Volume: 48, Issue: 6, Pages: 1759 - 1772
Published: Dec 28, 2020
Abstract
Deposition of misfolded alpha-synuclein (αSYN) aggregates in the human brain is one of the major hallmarks of synucleinopathies. However, a target-specific tracer to detect pathological aggregates of αSYN remains lacking. Here, we report the development of a positron emission tomography (PET) tracer based on anle138b, a compound shown to have therapeutic activity in animal models of neurodegenerative diseases.Specificity and selectivity of...
Paper Details
Title
[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates
Published Date
Dec 28, 2020
Volume
48
Issue
6
Pages
1759 - 1772
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