TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation
Abstract
The transcription factor MYC is deregulated in almost all human cancers, especially in aggressive lymphomas, through chromosomal translocation, amplification, and transcription hyperactivation. Here, we report that high expression of tribbles homologue 3 (TRIB3) positively correlates with elevated MYC expression in lymphoma specimens; TRIB3 deletion attenuates the initiation and progression of MYC-driven lymphoma by reducing MYC expression....
Paper Details
Title
TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation
Published Date
Dec 9, 2020
Journal
Volume
11
Issue
1
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