Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways
Abstract
Endothelial cell (EC) metabolism is thought to be one of the driving forces for angiogenesis. Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular EC, with an additivity with VEGF. ManN inhibits glycosylation in ECs and induces significant changes in N-glycan and O-glycan profiles. We further demonstrate that ManN and two N-glycosylation inhibitors...
Paper Details
Title
Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways
Published Date
Dec 10, 2020
Journal
Volume
11
Issue
1
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