What’s the cut‐point? A systematic review of tau pet thresholding methods

Background With increasing use of Alzheimer’s disease (AD) biomarker staging schemes, derivation of thresholds to determine biomarker positivity is becoming a critical methodological step. Recent advances in tau PET have made this modality a primary method for in vivo assessment of tau pathology. Given the heterogeneity in methodological decisions around tau PET positivity thresholding across studies, we conducted a systematic review of articles...