Graham M.L. Eglit
University of California, San Diego
PsychiatryPsychopathologyInternal medicineMental healthPsychologyTwin studyNeuroscienceCognitionCognitive psychologyOptimismPsychological interventionWell-beingApathyDepression (differential diagnoses)DiseaseMEDLINEDementiaParkinson's diseaseLonelinessBody mass indexTemporal lobePopulationAmyloid petAnxietyApolipoprotein ENeuroimagingClinical psychologyMedicineBiomarker (medicine)AmyloidProtective factor
26Publications
7H-index
106Citations
Publications 22
Newest
#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Olivia K. Puckett (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 30 authors...
INTRODUCTION The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression. METHODS Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LCCNR ). We examined LCCNR , cognition, amnestic mild cognitive imp...
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#1Hillary L Ditmars (BU: Boston University)H-Index: 1
#2Mark W. Logue (BU: Boston University)H-Index: 33
Last. Michael J. Lyons (BU: Boston University)H-Index: 85
view all 27 authors...
Background Clarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated with the subsequent onset of cardiometabolic health problems. Methods The study sample comprised 787 male twin veterans with polygenic risk score data who participated in the Harvard Twin Study of Substance Abuse ('baseline') and the longitudinal V...
1 CitationsSource
#1Alexandra J. Weigand (UCSD: University of California, San Diego)H-Index: 8
#2Kelsey R. Thomas (UCSD: University of California, San Diego)H-Index: 15
Last. Alzheimer’s Disease Neuroimaging Initiative (UCSD: University of California, San Diego)H-Index: 4
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Introduction Apolipoprotein E (APOE) interacts with Alzheimer's disease pathology to promote disease progression. We investigated the moderating effect of APOE on independent associations of amyloid and tau positron emission tomography (PET) with cognition. Methods For 297 nondemented older adults from the Alzheimer's Disease Neuroimaging Initiative, regression equations modeled associations between cognition and (1) cortical amyloid beta (Aβ) PET levels adjusting for tau and (2) medial temporal...
5 CitationsSource
#1Graham M.L. Eglit (UCSD: University of California, San Diego)H-Index: 7
#2Francesca V Lopez (VA: United States Department of Veterans Affairs)H-Index: 3
Last. J. Vincent Filoteo (UCSD: University of California, San Diego)H-Index: 31
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Background Apathy is a prevalent, multidimensional neuropsychiatric condition in Parkinson's disease (PD). Several authors have proposed apathy subtypes in PD, but no study has examined the classification of PD patients into distinct apathy subtypes, nor has any study examined the clinical utility of doing so. Objectives The current study used a data-driven approach to explore the existence and associated clinical characteristics of apathy subtypes in PD. Method The Apathy Scale (AS) was adminis...
1 CitationsSource
#1Alexandra J. Weigand (UCSD: University of California, San Diego)H-Index: 8
#2Graham M.L. EglitH-Index: 7
Last. Mark W. BondiH-Index: 71
view all 4 authors...
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#1Graham M.L. Eglit (UCSD: University of California, San Diego)H-Index: 7
#2Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
Last. William S. KremenH-Index: 70
view all 26 authors...
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#1William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
#2Mark Sanderson-Cimino (SDSU: San Diego State University)H-Index: 6
Last. Carol E. Franz (UCSD: University of California, San Diego)H-Index: 48
view all 15 authors...
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#1Mark Sanderson-Cimino (UCSD: University of California, San Diego)H-Index: 1
#2Jeremy A. Elman (University of California, Berkeley)H-Index: 15
view all 16 authors...
Objective Practice effects on cognitive tests obscure decline, thereby delaying detection of mild cognitive impairment (MCI). This reduces opportunities for slowing Alzheimer's disease progression and can hinder clinical trials. Using a novel method, we assessed the ability of practice-effect-adjusted diagnoses to detect MCI earlier, and tested the validity of these diagnoses based on AD biomarkers. Methods Of 889 Alzheimer's Disease Neuroimaging Initiative participants who were cognitively norm...
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#1Ellen E. Lee (UCSD: University of California, San Diego)H-Index: 15
#2Katherine J. Bangen (UCSD: University of California, San Diego)H-Index: 29
Last. Dilip V. Jeste (UCSD: University of California, San Diego)H-Index: 127
view all 10 authors...
Importance Wisdom is a neurobiological personality trait made up of specific components, including prosocial behaviors, emotional regulation, and spirituality. It is associated with greater well-being and happiness. Objective To evaluate the effectiveness of interventions to enhance individual components of wisdom. Data Sources MEDLINE and PsycINFO databases were searched for articles published through December 31, 2018. Study Eligibility Criteria Randomized clinical trials that sought to enhanc...
13 CitationsSource
#1Graham M.L. EglitH-Index: 7
#2Alexandra J. Weigand (UCSD: University of California, San Diego)H-Index: 8
Last. Katherine J. Bangen (UCSD: University of California, San Diego)H-Index: 29
view all 5 authors...
Hypertension is common among older adults and is believed to increase susceptibility to Alzheimer's disease, but mechanisms underlying this relationship are unclear. Hypertension also promotes circle of Willis atherosclerosis, which contributes to cerebral hypoperfusion and arterial wall stiffening, two potential mechanisms linking hypertension to Alzheimer's disease. To examine the role of circle of Willis atherosclerosis in the association between hypertension and Alzheimer's disease neuropath...
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