Icaritin Enhancing Bone Formation Initiated by Sub-Microstructured Calcium Phosphate Ceramic for Critical Size Defect Repair

Published on Dec 11, 2020in Frontiers in Materials2.705
· DOI :10.3389/FMATS.2020.598057
Haitao Peng4
Estimated H-index: 4
Jianxiao Li + 1 AuthorsGuoyu Lv
#1Mizhi Ji (Sichuan University)H-Index: 2
#2Hong Chen (Sichuan University)H-Index: 3
Last. Yu Zhong (Sichuan University)H-Index: 1
view all 6 authors...
In this study, ternary organic–inorganic composite bone cements of tricalcium silicate/sodium alginate/calcium sulfate hemihydrate (C3S/SA/CS) were successfully fabricated for in vitro and in vivo ...
3 CitationsSource
#1Lawrence E Murr (UTEP: University of Texas at El Paso)H-Index: 69
Abstract Additive manufacturing of porous, open-cellular metal or alloy implants, fabricated by laser or electron beam melting of a powder bed, is briefly reviewed in relation to optimizing biomechanical compatibility by assuring elastic (Young’s) modulus matching of proximate bone, along with corresponding pore sizes assuring osseointegration and vasculature development and migration. In addition, associated, requisite compressive and fatigue strengths for such implants are described. Strategie...
35 CitationsSource
#1Lukas A. van Dijk (UU: Utrecht University)H-Index: 3
#2Rongquan Duan (UT: University of Twente)H-Index: 5
Last. Joost D. de Bruijn (QMUL: Queen Mary University of London)H-Index: 38
view all 11 authors...
: As spinal fusions require large volumes of bone graft, different bone graft substitutes are being investigated as alternatives. A subclass of calcium phosphate materials with submicron surface topography has been shown to be a highly effective bone graft substitute. In this work, a commercially available biphasic calcium phosphate (BCP) with submicron surface topography (MagnetOs; Kuros Biosciences BV) was evaluated in an Ovine model of instrumented posterolateral fusion. The material was impl...
4 CitationsSource
#1Kang Gon Lee (UOU: University of Ulsan)H-Index: 2
#2Kang Sik Lee (Asan Medical Center)H-Index: 2
Last. Bu Kyu Lee (Asan Medical Center)H-Index: 4
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Bone graft materials are commonly used to regenerate various bone defects, but their application is often limited because of the complex defect shape in various clinical conditions. Hence, customized bone grafts using three-dimensional (3D) printing techniques have been developed. However, conventional simple bone defect models are limited for evaluating the benefits and manufacturing accuracy of 3D-printed customized bone grafts. Thus, the aim of the present study was to develop a complex-shape...
6 CitationsSource
#1Alexandra McMillan (Case Western Reserve University)H-Index: 8
#2Minh Khanh Nguyen (Case Western Reserve University)H-Index: 21
Last. Eben Alsberg (Case Western Reserve University)H-Index: 51
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Abstract High-density mesenchymal stem cell (MSC) aggregates can be guided to form bone-like tissue via endochondral ossification in vitro when culture media is supplemented with proteins, such as growth factors (GFs), to first guide the formation of a cartilage template, followed by culture with hypertrophic factors. Recent reports have recapitulated these results through the controlled spatiotemporal delivery of chondrogenic transforming growth factor-β1 (TGF-β1) and chondrogenic and osteogeni...
25 CitationsSource
#1Jingwei Zhang (Southwest Jiaotong University)H-Index: 5
#2Davide BarbieriH-Index: 12
Last. Huipin Yuan (Sichuan University)H-Index: 35
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The presence of micropores in calcium phosphate (CaP) ceramics has shown its important role in initiating inductive bone formation in ectopic sites. To investigate how microporous CaP ceramics trigger osteoinduction, we optimized two biphasic CaP ceramics (i.e., BCP-R and BCP-S) to have the same chemical composition, equivalent surface area per volume, comparable protein adsorption, similar ion (i.e., calcium and phosphate) exchange and the same surface mineralization potential, but different su...
32 CitationsSource
#1Jingwei Zhang (Southwest Jiaotong University)H-Index: 5
#2Xiaoman Luo (UT: University of Twente)H-Index: 10
Last. Huipin Yuan (UT: University of Twente)H-Index: 35
view all 7 authors...
The microporosity of calcium phosphate (CaP) ceramics has been shown to have an essential role in osteoinduction by CaP ceramics after ectopic implantation. Here we show that it is not the microporosity but the size of surface microstructural features that is the most likely osteogenic factor. Two tricalcium phosphate (TCP) ceramics, namely TCP-S and TCP-B, were fabricated with equivalent chemistry and similar microporosity but different sizes of surface microstructural features. TCP-S has a gra...
85 CitationsSource
#1Noel Davison (UT: University of Twente)H-Index: 8
#2Anne-Laure Gamblin (University of Nantes)H-Index: 4
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Bone graft substitutes such as calcium phosphates are subject to the innate inflammatory reaction, which may bear important consequences for bone regeneration. We speculate that the surface architecture of osteoinductive β-tricalcium phosphate (TCP) stimulates the differentiation of invading monocyte/macrophages into osteoclasts, and that these cells may be essential to ectopic bone formation. To test this, porous TCP cubes with either submicron-scale surface architecture known to induce ectopic...
60 CitationsSource
#1Noel DavisonH-Index: 8
#2Xiaoman LuoH-Index: 10
Last. J. D. de BruijnH-Index: 33
view all 7 authors...
A current challenge of synthetic bone graft substitute design is to induce bone formation at a similar rate to its biological resorption, matching bone’s intrinsic osteoinductivity and capacity for remodelling. We hypothesise that both osteoinduction and resorption can be achieved by altering surface microstructure of beta-tricalcium phosphate (TCP). To test this, two TCP ceramics are engineered with equivalent chemistry and macrostructure but with either submicron- or micron-scale surface archi...
45 CitationsSource
#1Xiaoman LuoH-Index: 10
#2Davide BarbieriH-Index: 12
Last. Huipin Yuan (UT: University of Twente)H-Index: 35
view all 6 authors...
Zinc-containing tricalcium phosphate (Zn-TCP) was synthesized to investigate the role of zinc in osteoblastogenesis, osteoclastogenesis and in vivo bone induction in an ectopic implantation model. Zinc ions were readily released in the culture medium. Zn-TCP with the highest zinc content enhanced the alkaline phosphatase activity of human bone marrow stromal cells and tartrate-resistant acid phosphatase activity, as well as multinuclear giant cell formation of RAW264.7 monocyte/macrophages. RAW2...
79 CitationsSource
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