Proteomic analysis of radio‐resistant breast cancer xenografts: Increased TGF‐β signaling and metabolism

Our previous studies have shown that MCF‐7 breast cancer cell line exposed to 6 Gy and allowed to recover for 7 days (D7‐6G) developed radio‐resistance. In this study, we have tested the ability of these cells to form tumors in severe combined immunodeficiency (SCID) mice and characterized these tumors by proteomic analyses. Untreated (MCF‐C) and D7‐6G cells (MCF‐R) were injected s.c. in SCID mice and tumor growth monitored. On Day 18, the mice...