Epithelial-to-mesenchymal transition in neutrophilic chronic rhinosinusitis

Barrier dysfunction, tissue fibrosis, and remodeling are essential processes of the pathophysiology of chronic rhinosinusitis (CRS). The role of epithelial-to-mesenchymal transition (EMT) has been assessed in various studies in CRS. In this review, we summarized the pathophysiologic mechanisms of EMT related to CRS, particularly neutrophilic CRS.Loss of epithelial characteristics due to EMT makes leaky epithelium, and transformed mesenchymal...