Identification of multi‐issue protein quantitative trait loci (pQTLs) for Alzheimer disease

Background Alzheimer disease (AD) is a neurodegenerative disease, affecting around 5.8 million people in the United States as of 2019. It has been widely studied, but there is still no effective treatment. Using large‐scale Genome‐wide association studies and whole genome/exome sequencing, researchers have identified common and rare variants associated disease risk that can be used to build prediction models. However, there are limited studies...