Labeling efficiency of Tb3+ conjugated CD133 monoclonal antibody nanocomplex targeting in vitro metastatic cancer cells

Efficient cancer treatment remains a huge challenge worldwide. As reported by the World HealthOrganization, the number of cancer patients is estimated to be 24 million in 2035, which is a 70% increasecompared to 14.1 million in 2012. The severity of cancer is due to the presence of cancer stem cells (CSCs),which are directly related to drug resistance, metastasis, and tumor relapse. Because of the unknown location ofthe primary tumor and/or the...